Plasma levels of 14:0, 16:0, 16:1n-7, and 20:3n-6 are positively associated, but 18:0 and 18:2n-6 are inversely associated with markers of inflammation in young healthy adults

Lipids
Maude PerreaultDavid M Mutch

Abstract

Inflammation is a recognized risk factor for the development of chronic diseases, such as type 2 diabetes and atherosclerosis. Evidence suggests that individual fatty acids (FA) may have distinct influences on inflammatory processes. The goal of this study was to conduct a cross-sectional analysis to examine the associations between circulating FA and markers of inflammation in a population of young healthy Canadian adults. FA, high-sensitivity C-reactive protein (hsCRP), and cytokines were measured in fasted plasma samples from 965 young adults (22.6 ± 0.1 years). Gas chromatography was used to measure FA. The following cytokines were analyzed with a multiplex assay: regulated upon activation normal T cell expressed and secreted (RANTES/CCL5), interleukin 1-receptor antagonist (IL-1Ra), interferon-γ (IFN-γ), interferon-γ inducible protein 10 (IP-10), and platelet-derived growth factor β (PDGF-ββ). Numerous statistically significant associations (p < 0.05, corrected for multiple testing) were identified between individual FA and markers of inflammation using linear regression. Myristic (14:0), palmitic (16:0), palmitoleic (16:1n-7), and dihomo-γ-linolenic (20:3n-6) acids were positively associated with all markers of inflammati...Continue Reading

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Citations

Apr 19, 2016·Nutrition Research and Practice·Eunyu Cho, Yongsoon Park
Oct 30, 2014·Frontiers in Immunology·Anja J de JongAndreea Ioan-Facsinay
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Megan S GraceBronwyn A Kingwell
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Nov 30, 2018·Frontiers in Nutrition·Gianna KühnGerald Rimbach
Dec 11, 2019·Nutrients·Urszula RadzikowskaMilena Sokolowska
Feb 8, 2020·Prostate Cancer and Prostatic Diseases·Bichen XueZongwei Wang
Aug 10, 2017·Frontiers in Immunology·Javier Rodríguez-CarrioAna Suárez
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Oct 2, 2020·Arthritis & Rheumatology·Javier Rodríguez-CarrioAna Suárez
Aug 28, 2018·Cellular Immunology·Yueshui ZhaoJing Shen

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