PMID: 9536921Apr 16, 1998Paper

Plasma levels of adrenomedullin in patients with acute myocardial infarction

Clinical Science
Y YoshitomiK Kangawa

Abstract

1. Adrenomedullin, a newly identified vasorelaxant peptide, participates in the regulation of the cardiovascular system. To investigate the pathophysiological significance of adrenomedullin in patients with acute myocardial infarction, we measured plasma levels of adrenomedullin. 2. Cardiac catheterization was performed on admission, after 1 day, and after 4 weeks in 36 patients with acute myocardial infarction. We measured plasma levels of adrenomedullin, atrial natriuretic peptide and brain natriuretic peptide in the right atrium, pulmonary artery and aorta. 3. Plasma levels of adrenomedullin in the right atrium (mean +/- SEM) were significantly increased on admission (4.2 +/- 2.6 h) in patients with acute myocardial infarction (10.6 +/- 1.0 pmol/l) compared with controls (5.2 +/- 0.3 pmol/l, P < 0.01). In addition, plasma levels of adrenomedullin were further elevated in patients with congestive heart failure (12.3 +/- 1.4 pmol/l) compared with patients without congestive heart failure (7.8 +/- 0.6 pmol/l, P < 0.01). In patients with congestive heart failure, plasma adrenomedullin on admission significantly correlated with atrial natriuretic peptide and brain natriuretic peptide. 4. These results suggest that plasma adrenome...Continue Reading

Citations

Jul 5, 2010·Pharmaceuticals·Naranjan S Dhalla, Alison L Müller
Mar 8, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Albertus BeishuizenAb Johan Groeneveld
Oct 7, 2004·Pharmacology & Therapeutics·David C BuntonJohn J V McMurray
Apr 18, 2006·Pharmacology & Therapeutics·Toshihiko IshimitsuHiroaki Matsuoka
Jun 12, 2012·Mediators of Inflammation·Elena TaleroSalvatore Cuzzocrea
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·S KojimaM Kuramochi
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Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K TerataD D Gutterman
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A StirratM R MacLean
Feb 6, 2021·Journal of Clinical Medicine·Katarzyna CzajkowskaTomasz Hryszko
Apr 5, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Takeshi YoshimotoMasafumi Ihara
Jan 16, 2019·Archives of Medical Research·Nancy S SaadPaul M L Janssen
Nov 11, 1999·European Journal of Pharmacology·T HorioK Kangawa

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