Plasma levels of apolipoprotein A1 in malaria-exposed primigravidae are associated with severe anemia.

PloS One
David C SimpsonMichal Fried

Abstract

Plasmodium falciparum placental malaria (PM) contributes to 10,000 maternal deaths due to severe anemia (SA) each year in Africa, primarily among primigravid women who are most susceptible. Increased levels of proinflammatory cytokines like TNF-alpha are associated with maternal anemia in first time mothers but not in other women. Here we aimed to identify additional changes in the plasma proteome associated with pregnancy malaria that may contribute to the development of malaria-related maternal anemia. A semi-quantitative mass spectrometry approach was used to compare the relative abundance of plasma proteins in anemic versus non-anemic women with PM. Levels of 24 proteins differed significantly between anemic and non-anemic primigravidae, including several lipid metabolism proteins and molecular transport proteins involved in the acute phase response signaling network. These differences were not observed in multigravid women who enjoy specific immunity that protect them from PM. In a confirmatory study of a larger cohort of primigravid women, levels of the lipid metabolism protein Apolipoprotein (Apo)-AI were significantly lower in PM+ women with SA. Apo-AI levels are significantly lower in severely anemic primigravidae with...Continue Reading

References

Jul 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·C VerganiN Dioguardi
Mar 1, 1990·Journal of Internal Medicine·I Nilsson-Ehle, P Nilsson-Ehle
Jun 15, 1989·The New England Journal of Medicine·G E GrauP H Lambert
Jul 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·A F Fleming
Jan 1, 1994·Critical Reviews in Immunology·S A RobertsonT G Wegmann
Mar 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·J R ZuckerC C Campbell
Nov 6, 1998·Nature·M FriedP E Duffy
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·V MooserR Chioléro
Oct 27, 2001·Tropical Medicine & International Health : TM & IH·C E ShulmanK Marsh
Apr 16, 2002·Journal of the American Society for Mass Spectrometry·Roger E MooreTerry D Lee
Nov 22, 2002·Parasitology Research·Jean-François FaucherPeter G Kremsner
Mar 20, 2003·Journal of Proteome Research·James X PangGregory J Opitek
Nov 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·K CRAMERS PEHRSON
Oct 24, 2003·Biochimica Et Biophysica Acta·Michael J HaasArshag D Mooradian
Dec 25, 2003·Journal of Proteome Research·Ji GaoStanley A Hefta
Jun 28, 2005·Molecular & Cellular Proteomics : MCP·William M OldNatalie G Ahn
Nov 4, 2006·Journal of Proteome Research·Bing ZhangNagiza F Samatova
Jan 24, 2008·Infection and Immunity·Edward R KabyemelaPatrick E Duffy
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert E GersztenLorraine B Ware
May 27, 2008·The Journal of Infectious Diseases·Edward R KabyemelaPatrick E Duffy

❮ Previous
Next ❯

Citations

Oct 25, 2012·BMC Public Health·Mieke Van HemelrijckSabine Rohrmann
May 13, 2011·Cancer Causes & Control : CCC·Mieke Van HemelrijckLars Holmberg
Mar 31, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Xia GuoAbulizi Abudula
Mar 4, 2015·Biomarkers in Medicine·Esmée RuizendaalPetra F Mens

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Ingenuity Pathways Analysis ( IPA )
Ingenuity Pathways Analysis
Sequest
Statview
PeptideProphet

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.