PMID: 9174847Apr 1, 1997Paper

Plasma levels of beta-endorphin during the menstrual cycle

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
J FerrerB Marín

Abstract

During recent years, many research teams have suggested a possible role of endogenous opiates in the control of the menstrual cycle. The level of immunoreactive beta-endorphin was measured on different days during the ovulatory cycle of 131 healthy volunteers. The levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17 beta-estradiol and progesterone were also measured. The graphic representation of opiate levels during the female menstrual cycle, where day O is the day of ovulation, shows that plasmatic beta-endorphin levels are not stable throughout. The levels increase progressively during the follicular phase, reaching a maximum (mean 139.49 pg/ml, SD 42.23 pg/ml, 95% confidence interval 121.22-157.75 pg/ml) 4 days before ovulation. During the periovulatory period (days-3 to +3) levels of beta-endorphin are very stable (mean day 0, 27.8 pg/ml, SD 6.36 pg/ml, 95% confidence interval 19.29-27.83 pg/ml) and low (p < 0.05), followed by a renewed increase during the luteal phase (mean day + 5, 87.86 pg/ml, SD 36.49 pg/ml) where a maximum level (mean 102.78 pg/ml, SD 30.35 pg/ml) is reached 24 h before the next menses. The beta-endorphin level has a negative correlation with the LH level (r = -0.50, p < 0.001) ...Continue Reading

References

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Citations

Aug 11, 2010·Current Pain and Headache Reports·Katy Vincent, Irene Tracey
Jul 27, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Raj Kumar YadavSushil Chandra Mahapatra
Nov 12, 2009·Endocrine Reviews·Cassidy VuongTheodore C Friedman
Feb 19, 2008·Acta Veterinaria Hungarica·J StaszkiewiczS Okrasa
Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·U Halbreich
Jun 16, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Martinez-GuisasolaE Alonso-Briz
Mar 8, 2021·Trends in Endocrinology and Metabolism : TEM·Nikolai JaschkeTilman D Rachner

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