Plasma levels of cellular fibronectin in patients with localized and metastatic renal cell carcinoma

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
A HegeleP J Olbert

Abstract

Clinical markers for renal cell carcinoma (RCC) are lacking. Fibronectin is a glycoprotein that plays an important role in cellular attachment and cell spread. The aim of this study was to test the clinical suitability of cellular fibronectin (cFN) in plasma as a tumor marker for RCC and to determine a possible relationship between cFN plasma levels and stage of disease. Therefore, cFN was determined in the plasma of patients with localized (n = 40) and metastatic (n = 20) RCC using a time-resolved fluorescence immunoassay. Fifty patients with different non-malignant urological disorders were recruited as a control group. In the control group, mean cFN plasma levels amounted to 553 ng/ml. In patients with localized RCC, plasma concentrations of cFN were increased (1,295 ng/ml; p < 0.01). Patients with metastatic disease had the highest concentrations (3,842 ng/ml). Statistical analysis demonstrated a significant difference between controls, and patients with localized and metastatic RCC (p < 0.01), with a sensitivity of 80%, a specificity of 78% and a positive predictive value of 81% using a cutoff value of 540 ng/ml (receiver-operating characteristic curve analysis). These data suggest that cFN is not a realistic marker for th...Continue Reading

Citations

Feb 20, 2013·Clinical & Experimental Metastasis·Cheng-Hung ChouChen Chang
Feb 23, 2010·Asian Journal of Andrology·Maja M Kosanović, Miroslava M Janković
Jan 24, 2014·Journal of Analytical Methods in Chemistry·Showkat A BhawaniA Mohammad
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Sep 10, 2020·Journal of Receptor and Signal Transduction Research·Jianan WangChengbin Wang

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