Plasma levels of clonidine following epidural bolus injection in children

Acta Anaesthesiologica Scandinavica
G IvaniP A Lönnqvist

Abstract

The use of clonidine as an adjunct to epidural administration of local anesthetics in children has been reported to substantially improve the duration and quality of postoperative analgesia. The aims of the present study were to determine the pharmacokinetic profile and to investigate the interaction between postoperative sedation and analgesia after epidurally administered clonidine in children. Plasma levels of clonidine (0-10 h postop) and assessment of postoperative analgesia and sedation (0-24 h postop) were performed at predetermined intervals following lumbar epidural administration of bupivacaine 2.0 mg/kg and clonidine 2 mg/kg in 8 children undergoing ureteral re-implantation surgery using general anesthesia (age range: 1-9 yr, weight range: 9-41 kg). Plasma levels of clonidine were analyzed by radioimmunoassay, and sedation and analgesia were assessed by previously described scoring systems. The venous plasma pharmacokinetics of clonidine following epidural administration showed a considerable interindividual variation. Cmax and Tmax values of clonidine were found to be within the 0.45-0.77 ng/mL and 48-193 min range, respectively. The time to absorb 95% of the clonidine dose from the epidural space into plasma varied...Continue Reading

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Citations

Apr 11, 2000·Acta Anaesthesiologica Scandinavica·G IvaniP A Lönnqvist
Apr 4, 2003·Biological & Pharmaceutical Bulletin·Kenji SumiyaYukinao Kohda
Feb 8, 2006·Biological & Pharmaceutical Bulletin·Masato HommaYukinao Kohda
Oct 5, 2010·Indian Journal of Anaesthesia·Sukhminder Jit Singh BajwaAparajita Panda
Sep 3, 2003·Paediatric Anaesthesia·Mark AnserminoCarolyne Montgomery
Sep 5, 2007·Paediatric Anaesthesia·Amanda L PottsBrian J Anderson
Aug 26, 2010·Paediatric Anaesthesia·Peter LarssonBrian J Anderson
Jun 16, 2004·Intensive Care Medicine·Sara Arenas-LópezIan A Murdoch
Mar 15, 2002·Anesthesiology Clinics of North America·Gregory B Hammer
Sep 18, 2014·Paediatric Anaesthesia·Per-Arne Lönnqvist
Aug 1, 2014·British Journal of Anaesthesia·S Arenas-LopezS M Tibby
Jan 20, 2016·The Annals of Pharmacotherapy·Vonya N StreetzDennis F Thompson
Mar 15, 2002·Anesthesiology Clinics of North America·Sabine Kost-Byerly
Jun 1, 2006·Current Opinion in Anaesthesiology·Brian J Anderson, Greta M Palmer
Jan 16, 2009·Paediatric Anaesthesia·Nicole AlmenraderStaffan Eksborg
Oct 5, 2006·Current Opinion in Anaesthesiology·G Ivani, P De Negri
May 29, 2001·Anesthesia and Analgesia·G B Hammer
Mar 14, 2020·Paediatric Anaesthesia·Bettina N NielsenArash Afshari
Jul 11, 1998·Anaesthesia·G IvaniP A Lonnqvist

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