Plasma levels of endothelin-1 at rest and after exercise in patients with moderate congestive heart failure

International Journal of Cardiology
P de GrooteG Ducloux

Abstract

Plasma levels of endothelin-1 are increased in patients with severe congestive heart failure related to various etiologies. However, conflicting data have been published in patients with moderate congestive heart failure. Moreover, the effect of exercise on plasma levels of endothelin-1 is not precisely known. We determined the plasma levels of endothelin-1 in a homogenous group of patients with idiopathic dilated cardiomyopathy in stage II of the New York Heart Association functional classification at rest and at peak exercise. In this group of patients, plasma levels of endothelin-1 were increased compared to a control group (2.9 +/- 0.27 vs. 1.96 +/- 0.24 pmol/l, P < 0.01, mean +/- S.E.M.), as were plasma levels of atrial natriuretic peptide (26.3 +/- 6.3 vs. 2.95 +/- 0.7 pmol/l, P < 0.001), plasma renin activity (12.6 +/- 2.98 vs. 1.75 +/- 0.23 ng/ml per h, P < 0.001) and plasma levels of aldosterone (217 +/- 29.3 vs. 154 +/- 18.8 pg/ml, P < 0.05). In contrast to the other hormones, exercise did not increase plasma levels of endothelin-1. There was no correlation between plasma levels of endothelin-1 and plasma levels of atrial natriuretic peptide, and no correlation between left ventricular ejection fraction, peak oxygen c...Continue Reading

References

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Citations

Jul 25, 2000·European Journal of Clinical Investigation·G N OnuohaD P Nicholls
Sep 17, 2004·Annales de cardiologie et d'angéiologie·P de GrooteC Bauters
Mar 12, 2004·European Journal of Heart Failure·Andreas KjaerClaus Leth Petersen
Oct 16, 1999·Proceedings of the Association of American Physicians·F Sam, W S Colucci
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C P ChengW C Little

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