Plasma levels of free fatty acid differ in patients with left ventricular preserved, mid-range, and reduced ejection fraction

BMC Cardiovascular Disorders
Ning ZhuXuyong Zhao

Abstract

Free fatty acids (FFAs) predicted the risk of heart failure (HF) and were elevated in HF with very low left ventricular ejection fraction (LVEF) compared to healthy subjects. The aim of this study was to investigate whether total levels of FFA in plasma differed in patients with HF with preserved (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF) and the association with the three categories. One hundred thirty-nine patients with HFpEF, HFmrEF and HFrEF were investigated in this study. Plasma FFA levels were measured using commercially available assay kits, and LVEF was calculated by echocardiography with the Simpson biplane method. Dyspnea ranked by New York Heart Association (NYHA) was also identified. FFA concentrations were higher in HFrEF than in HFmrEF and HFpEF, respectively (689 ± 321.5 μmol/L vs. 537.9 ± 221.6 μmol/L, p = 0.036; 689 ± 321.5 μmol/L vs. 527.5 ± 185.5 μmol/L, p = 0.008). No significant differences in FFA levels were found between HFmrEF and HFpEF (537.9 ± 221.6 μmol/L vs. 527.5 ± 185.5 μmol/L, p = 0.619). In addition, we found a negative correlation between FFA levels and LVEF (regression coefficient: - 0.229, p = 0.004) and a positive correlation between FFAs and NYHA class (regression co...Continue Reading

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Citations

Jun 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Vesna DegoricijaSaša Frank
Dec 5, 2020·The Canadian Journal of Cardiology·Jacinthe BouletJean-Lucien Rouleau
Jul 11, 2021·Journal of Clinical Lipidology·Sarah O NomuraMichael Y Tsai
Jul 3, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Andrea Del CampoHugo E Verdejo

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