Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in preeclampsia

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
V C SandrimR C Cavalli

Abstract

Although the role of soluble fms-like tyrosine kinase 1 (sFLT-1) in preeclampsia is well-established, the mechanism related to its synthesis remains poorly understood. We evaluated the association among the circulating microRNAs (miRs) and sFLT-1 levels in preeclampsia pregnant women. For this purpose, we measured the plasma sFLT-1 levels in 24 preeclampsia women and selected from these, three subjects with the lowest and three with the highest levels of sFLT-1 in order to screen for potential miRs associated with plasmatic sFLT-1 concentrations using a polymerase chain reaction-array (PCR-array) methodology. From screening results, we found three statistically different expressed miRs with fold change (FC-high/low levels) ≥3.0: miR-195-5p (FC = 5.2 increase in group with high sFLT-1 levels), miR-16-5p (FC = 3.2; increase in group with high sFLT-1 levels), and miR-375 (FC = -3.0; decrease in group with high sFLT-1 levels) which were later validated in all samples (n = 24). To correlate these miRs and plasma sFLT-1 levels, we used two extremes of analysis. In one part, we compared 12 preeclampsia women with the lowest sFLT-1 levels (L-50% group) to 12 with the highest levels (50% H group); and in the second analysis, 6 preeclamp...Continue Reading

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Citations

Sep 27, 2018·Journal of Cellular Physiology·Yan LvMingming Lv
Apr 8, 2020·Biology of Sex Differences·Laila AryanMansoureh Eghbali
Jul 18, 2017·Journal of Pregnancy·Meng CaiAsif Ahmed
Jul 1, 2020·Biomolecules·Manoj Kumar JenaNihar Ranjan Nayak
Nov 25, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Utku AkgörFiliz Çayan

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