Plasma Levels of Inflammatory Biomarkers in Peripheral Arterial Disease: Results of a Cohort Study

Angiology
Salvatore Santo SignorelliSergio Neri

Abstract

Previous research analyzed the level of plasma inflammatory markers in patients with coronary disease, but very few studies have evaluated these markers in patients with peripheral arterial disease (PAD). The objective of this study was to investigate the plasma levels of inflammatory markers in patients with PAD and in healthy controls. The following plasma levels of biomarkers were measured in 80 patients with PAD (mean age 68 ± 5 years) and in 72 healthy participants (mean age 67 ± 6 years): interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), L-selectin (LS), neopterin (N), P-selectin (PS), E-selectin (ES), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and matrix metalloproteinase 2 (MMP-2), and 9 (MMP-9). Significantly higher levels of IL-6 (P < .001), TNF-α (P < .0001), ES (P < .0001), LS (P < .0001), PS (P < .0001), ICAM-1 (P < .001), VCAM-1 (P < .001), N (P < .001), MMP-2 (P < .001), and MMP-9 (P < .005) were found in the patients with PAD. Patients with PAD show a inflammation marker profile different from that of control participants. Reducing the high plasma levels of inflammatory markers could be a new therapeutic approach both for the prevention and the treatment of PAD.

References

Feb 6, 1992·The New England Journal of Medicine·M H CriquiD Browner
Aug 1, 1991·Atherosclerosis·F TatzberH Esterbauer
Jan 14, 1999·The New England Journal of Medicine·R Ross
May 24, 2001·The New England Journal of Medicine·W R Hiatt
Aug 21, 2001·Angiology·F G FowkesA J Lee
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Apr 22, 2003·Vascular and Endovascular Surgery·Satoshi SaitoKensuke Esato
Apr 30, 2003·Archives of Internal Medicine·Jill J F BelchUNKNOWN Prevention of Atherothrombotic Disease Network
Jul 16, 2003·The American Journal of Cardiology·Mary M McDermottJoseph R Schneider
Oct 28, 2003·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Patrizia FerroniCesare Alessandri
Nov 6, 2004·Current Opinion in Lipidology·Kausik K Ray, Christopher P Cannon
Nov 6, 2004·Current Opinion in Lipidology·Joseph M Li, Kenneth J Mukamal
Jan 7, 2005·The New England Journal of Medicine·Paul M RidkerUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Inv
Jan 15, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K CassarJ Brittenden
Feb 5, 2005·Pathophysiology of Haemostasis and Thrombosis·H Roger Lijnen
Mar 16, 2005·Archives of Internal Medicine·Karen L MargolisUNKNOWN Women's Health Initiative Research Group
Jul 14, 2005·Journal of Vascular Surgery·Jamal BaraniAnders Gottsäter
Oct 14, 2005·Seminars in Vascular Medicine·Gordon D O LoweJohn Danesh
Oct 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Dietrich RothenbacherHubert Kolb
Aug 7, 2007·Biochemical Pharmacology·Joseph D Raffetto, Raouf A Khalil
Aug 29, 2007·Journal of Thrombosis and Haemostasis : JTH·M WoodwardG Lowe

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Citations

Aug 25, 2016·Journal of Diabetes·Shao-Ling YangJing-Tao Dou
Jul 13, 2019·International Journal of Immunopathology and Pharmacology·Katia ManganoAntonio Di Cataldo
Dec 12, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Cuicui WangClarice R Weinberg
Jan 31, 2020·Oxidative Medicine and Cellular Longevity·Klara KomiciGraziamaria Corbi
May 10, 2017·Angiology·Selcuk KucukseymenSakir Arslan
Jul 14, 2017·Angiology·Salvatore Santo Signorelli
Jan 11, 2020·Open Medicine·Franca VergalitoRoberto Di Marco
Mar 30, 2017·Molecular Medicine Reports·Gea Oliveri ContiMargherita Ferrante
Mar 7, 2021·International Journal of Molecular Sciences·Federico BiscettiAndrea Flex
Apr 4, 2021·International Journal of Molecular Sciences·Goren Saenz-PipaonCarmen Roncal

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Methods Mentioned

BETA
coronary bypass
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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