Plasma levels of insulin-like growth factor binding protein-3 in acute trauma patients

Metabolism: Clinical and Experimental
M JeevanandamS R Petersen

Abstract

Insulin-like growth factors (IGFs) are a family of polypeptides that regulate cell growth. Their action and bioavailability are modified by binding proteins such as IGF binding protein-3 (IGFBP-3). Plasma IGFBP-3 level was found to be growth hormone (GH)-dependent, which makes detection of IGFBP-3 useful in the evaluation of GH secretion. In the early catabolic flow phase of severe injury, when plasma levels of GH and IGF-1 are low versus uninjured levels, the role of IGFBP-3 has not been investigated. We have measured basal levels of these polypeptide hormones in 16 adult (13 men and three women aged 47 +/- 7 years) severely injured (Injury Severity Score, 32 +/- 2), hypermetabolic resting energy expenditure [REE] to basal energy expenditure [BEE] ratio, 1.30 +/- 0.05), ventilator-dependent, multiple-trauma patients within 48 to 60 hours of injury when the patients were receiving maintenance fluids without calories or nitrogen. These basal values were compared with those of 16 age-matched postabsorptive normals. In the catabolic flow phase of injury, plasma levels of GH, IGF-1, and IGFBP-3 were significantly reduced by 50%, 46%, and 45%, respectively. There was a significant linear inverse relationship between IGFBP-3 and age ...Continue Reading

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Citations

Jul 14, 2001·Burns : Journal of the International Society for Burn Injuries·J F Aili LowD N Herndon
May 10, 2005·European Journal of Endocrinology·Marta BondanelliEttore C degli Uberti
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Sep 25, 2020·Expert Review of Endocrinology & Metabolism·Georgia Ntali, Stylianos Tsagarakis
Apr 24, 2004·Clinical Endocrinology·Amar AghaChristopher J Thompson

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