Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease.

Lipids in Health and Disease
Wei GaoLian-Sheng Wang

Abstract

Hyperlipidemia plays a crucial role in the development and progression of coronary artery disease (CAD). Recent studies have identified that microRNAs (miRNAs) are important regulators of lipid metabolism, but little is known about the circulating levels of lipometabolism-related miRNAs and their relationship with the presence of CAD in patients with hyperlipidemia. In the present study, we enrolled a total of 255 hyperlipidemia patients with or without CAD and 100 controls with normal blood lipids. The plasma levels of four known lipometabolism-related miRNAs, miR-122, miR-370, miR-33a, and miR-33b were quantified by real-time quantitative PCR. Blood levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol were determined. Furthermore, the severity of CAD was assessed with the Gensini score system based on the degree of luminal narrowing and its geographic importance. Our results revealed for the first time that plasma levels of miR-122 and miR-370 were significantly increased in hyperlipidemia patients compared with controls, and the levels of miR-122 and miR-370 were positively correlated with TC, TG, and LDL-C levels in both hyperlipidemia pat...Continue Reading

References

Jan 1, 1988·Annals of Biomedical Engineering·W P SantamoreW C Little
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Jan 22, 2005·Annual Review of Medicine·David E Moller, Keith D Kaufman
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Mar 28, 2008·Nature·Joacim ElménSakari Kauppinen
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 27, 2009·The Journal of Biological Chemistry·Shimin DongChunxiang Zhang
Feb 4, 2010·Journal of Lipid Research·Dimitrios IliopoulosVassilis I Zannis
Feb 6, 2010·Stroke; a Journal of Cerebral Circulation·Jordi Jimenez-CondeNatalia S Rost
Mar 17, 2010·Biochemical and Biophysical Research Communications·Menno HoekstraErik A L Biessen
May 15, 2010·Science·S Hani Najafi-ShoushtariAnders M Näär
May 15, 2010·Science·Katey J RaynerCarlos Fernández-Hernando
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tyler J MarquartAngel Baldán
Aug 25, 2010·The Journal of Biological Chemistry·Isabelle GerinGuido T Bommer
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takahiro HorieToru Kita
Oct 6, 2010·Circulation. Cardiovascular Genetics·Maarten F CorstenBlanche Schroen
Dec 24, 2010·Current Opinion in Lipidology·Carlos Fernández-HernandoKathryn J Moore
Jan 5, 2011·Biochemical and Biophysical Research Communications·Qiuwang ZhangMichael J Kutryk
Oct 21, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephan FichtlschererStefanie Dimmeler

❮ Previous
Next ❯

Citations

Nov 22, 2013·PloS One·Yuri D'AlessandraGiulio Pompilio
Jul 25, 2013·International Journal of Molecular Sciences·Li-Hua GuoJin-Sheng He
Sep 24, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wu YungangXinliang Pan
Dec 3, 2014·Trends in Molecular Medicine·Emeline GorettiYvan Devaux
Mar 19, 2013·Journal of Lipid Research·Katey J Rayner, Elizabeth J Hennessy
Feb 25, 2014·Current Genetic Medicine Reports·Carlos Fernández-Hernando, Angel Baldán
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Nathan L PriceCarlos Fernández-Hernando
Dec 22, 2012·Expert Review of Molecular Diagnostics·Mariano J ScianValeria R Mas
Jul 1, 2014·Scientific Reports·Xing Chen, Gui-Ying Yan
Nov 21, 2012·Molecular Nutrition & Food Research·Cinta BladéAnna Arola-Arnal
Feb 19, 2014·Journal of Cellular and Molecular Medicine·Leni MoldovanMelissa Piper
Feb 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Yemiao Chen, Catherine M Verfaillie
Mar 12, 2015·Journal of Minimally Invasive Gynecology·Warren B NothnickJohn R Lue
Dec 25, 2012·Atherosclerosis·Wu-Jun ChenChao-Ke Tang
Jul 5, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lynn M BekrisJames B Leverenz
Apr 22, 2016·European Heart Journal·Peter WilleitManuel Mayr
Apr 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yogita K Adlakha, Neeru Saini
Jan 13, 2015·Molecular and Cellular Biochemistry·Yan JinJun Yang
Jul 1, 2016·Cardiovascular Research·Rokas NavickasPaul Holvoet
Sep 7, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Nuno Cortez-DiasFrancisco J Enguita
Sep 7, 2016·Pharmacology & Therapeutics·Danielle L Michell, Kasey C Vickers
Oct 4, 2016·Atherosclerosis·Joy N Jones BuieHongkuan Fan
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Da Zhi LiuFrank R Sharp
Dec 5, 2017·PloS One·Paola de CandiaAntonio Ceriello
Jun 19, 2018·Journal of Developmental Origins of Health and Disease·B SiddeekU Simeoni
Oct 23, 2015·Current Atherosclerosis Reports·Dorothee KaudewitzManuel Mayr

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
transfection

Software Mentioned

SDS Relative Quantification
SPSS
PASW

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Takahiro HorieToru Kita
Arteriosclerosis, Thrombosis, and Vascular Biology
Stephan FichtlschererStefanie Dimmeler
Circulation Research
Stephan FichtlschererStefanie Dimmeler
© 2021 Meta ULC. All rights reserved