Plasma levels of lipoprotein-associated phospholipase A(2) are increased in patients with β-thalassemia.

Journal of Lipid Research
Alexandros D TselepisDimitrios C Alexopoulos

Abstract

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA(2) activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients with β-thalassemia. Thirty-five patients with β-thalassemia major (β-TM) and 25 patients with β-thalassemia intermedia (β-TI) participated in the study. Lp-PLA(2) activity and mass were measured in total plasma, in apolipoprotein (apo)B-depleted plasma (HDL-Lp-PLA(2)), and in LDL subclasses. Lp-PLA(2) activity produced and secreted from peripheral blood monocytes in culture was also determined. Patients with β-thalassemia are characterized by a predominance of small-dense LDL particles, increased oxidative stress, and very high plasma levels of Lp-PLA(2) mass and activity, despite low LDL-cholesterol levels. A significant positive correlation between plasma Lp-PLA(2) activity or mass and 8-isoprostane (8-epiPGF2a) and ferritin levels as well as intima-media thickness (IMT) values was observed. An increase in secreted and cell-associated Lp-PLA(2) activity from monocytes in culture was observed in both patient groups. The HDL-Lp-PLA(2) activity and mass as well as the ratio o...Continue Reading

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Citations

May 18, 2011·Acta Haematologica·Maria Eliana LaiAntonella Mandas
Mar 10, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Oana VittosElena Moldoveanu
Oct 28, 2015·BioMed Research International·Anna SödergrenSolveig Wållberg-Jonsson
Feb 15, 2015·Annals of Vascular Surgery·Thomas KotsisKonstantinos Speggos
Mar 11, 2017·BMC Pediatrics·Laila M SheriefWesam A Mokhtar
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Soheila SetoodehMohammad Ali Takhshid
Jul 24, 2021·Expert Review of Hematology·Osama Ahmad IbrahimWalaa H Mohammad Ibrahim

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