Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis.

Journal of Clinical Laboratory Analysis
Tamara DjurićDragan Alavantić

Abstract

Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P<0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P<0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (...Continue Reading

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Citations

May 3, 2013·PloS One·Nilminie RathnayakeAnders Gustafsson
Dec 3, 2014·Pharmacology & Therapeutics·Shu Ye
Mar 11, 2011·Cytokine & Growth Factor Reviews·Eline DejonckheereClaude Libert
Aug 16, 2017·The Journal of Pharmacy and Pharmacology·Anna Justina SvaganKorbinian Löbmann

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