Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease

BMC Pediatrics
Siqi FengQijian Yi

Abstract

Monokines induced by interferon-gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL). Forty-three children patients with KD and 19 healthy controls were included in this study. General characteristics were obtained from all subjects. Plasma concentrations of chemotactic factors of MIG/CXCL9 and TARC/CCL17 were measured by enzyme-linked immunosorbent assay (ELISA) for all subjects. Plasma levels of MIG/CXCL9, TARC/CCL17, and the ratios of MIG/TARC were significantly elevated in pediatric patients with KD compared to those in the control group. There were also significantly higher levels of MIG/CXCL9, TARC/CCL17, MIG/TARC ratios and prominently lower hemoglobin (Hb) levels in KD with CAL compared to KD without corona...Continue Reading

References

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Citations

Oct 6, 2016·Open Forum Infectious Diseases·Raymond M JohnsonAnupam B Kharbanda
Jan 6, 2018·Clinical Rheumatology·Akira HachiyaKazunaga Agematsu
Aug 20, 2019·The Cochrane Database of Systematic Reviews·Noyuri YamajiRintaro Mori
Nov 11, 2019·Nature Reviews. Rheumatology·Yoshishige MiyabeAndrew D Luster
Dec 19, 2015·BMC Genomics·Anne H RowleyTodd N Wylie
Jan 7, 2020·The Journal of Dermatology·Mao SatakeMasutaka Furue

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ESR

Software Mentioned

SPSS19

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