PMID: 9191442May 1, 1997Paper

Plasma levels of prekallikrein, alpha-2-macroglobulin and C1-esterase inhibitor in patients with urticarial reaction to contrast media

Acta Radiologica
R MikkonenM Syrjälä

Abstract

The plasma levels of prekallikrein, alpha-2-macroglobulin and C1-esterase inhibitor (C1 INH) in patients with previous urticarial reaction to contrast media (CM) were compared to those of a group of nonreacting age- and sex-matched controls. This study evaluated the value of these laboratory variables in predicting acute and delayed urticarial-type reactions. The study comprised 44 patients (reactors) with acute (n = 29) or delayed (n = 15) urticaria after administration of CM, and a group of age- and sex-matched controls. In the reactors, the levels of prekallikrein and alpha-2-macroglobulin were higher (p < 0.0001) and the level of C1 INH lower (p < 0.0001) than those of the controls. The level of prekallikrein decreased with increasing age (p = 0.02) and women had higher values than men (p = 0.0054). The level of alpha-2-macroglobulin was age-dependent (p = 0.006). Although high plasma prekallikrein activity, high plasma alpha-2-macroglobulin activity, and low plasma C1 INH activity are associated with urticaria-type reaction to CM, their value in predicting urticarial reaction is limited because prekallikrein is age- and sex-dependent, and alpha-2-macroglobulin is age-dependent.

Citations

Jun 1, 2000·Clinical Reviews in Allergy & Immunology·P L Lieberman, R L Seigle
Nov 4, 2005·Springer Seminars in Immunopathology·Marco CicardiBenedetta Cicardi
Sep 26, 2013·International Journal of Legal Medicine·Cristian PalmierePatrice Mangin
Oct 5, 2001·Expert Opinion on Pharmacotherapy·M Kirschfink, T E Mollnes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.