PMID: 9660101Jul 11, 1998Paper

Plasma levels of R- and S-salsolinol are not increased in "de-novo" Parkinsonian patients

Journal of Neural Transmission
T MüllerW Kuhn

Abstract

An augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL) or an increased N-methylation of these compounds has been addressed by various investigators as putative pathophysiologic mechanisms in Parkinson's disease (PD). Aim of this study was (1) to investigate putative relations between plasma levels of dopamine and R- and S-enantiomers of SAL and (2) whether these metabolic precursors of the neurotoxic N-methylated-SAL (NMSAL) are elevated in untreated "de-novo" Parkinsonian patients compared to age- and sex-matched healthy controls. Plasma levels of R- and S-SAL and dopamine did not significantly (R-SAL: p=0.61, S-SAL: p=0.51, dopamine: p=0.84) differ in both groups. Parkinsonian patients' R-SAL plasma levels were inversely related to intensity (p=0.03, r =-0.42) and duration of PD (p=0.03, r=-0.43) in contrast to S-SAL and dopamine. Dopamine levels were not associated to R-SAL (p=0.88, r2=0.0008) and S-SAL (p=0.088, r2=0.12) neither in Parkinsonian patients nor in controls. We conclude, that an upregulation of N-methylation of tetrahydroisoquinolines takes place in PD by enzymes such as neutral N-methyltransferase specific for R-SAL. The activity of this enzyme has been found elevated in parkinsonian lympho...Continue Reading

Citations

May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·T MüllerH Rommelspacher
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Frank MusshoffBurkhard Madea
Mar 1, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zhe QuanYi-Ming Liu
Jan 2, 2014·Brain and Behavior·Craig F FerrisTakao Yagi
May 29, 2008·Expert Review of Neurotherapeutics·Thomas Müller
Feb 21, 2002·Journal of Neuropathology and Experimental Neurology·Richard B ParsonsDavid B Ramsden

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