PMID: 8586118Oct 1, 1995Paper

Plasma levels of soluble tumour necrosis factor receptors are increased in coal miners with pneumoconiosis

The European Respiratory Journal
R P Schins, P J Borm

Abstract

Among other cytokines, tumour necrosis factor (TNF)-alpha is considered to play a key role in the development of mineral dust related fibrosis. Previously, we showed that ex-vivo release of TNF by peripheral blood monocytes is a marker for progression of coal workers' pneumoconiosis (CWP). Since soluble TNF receptors (sTNF-Rs) are believed to play an important regulatory role in systemic effects of TNF, we measured plasma levels of sTNF-R55 and sTNF-R75 in coal miners with (n = 28) or without (n = 76) CWP and in nonexposed controls (n = 29). sTNF-R75 levels were significantly increased in miners with CWP (2.09 +/- 0.44 ng.mL-1) versus the nonexposed controls (1.86 +/- 0.23 ng.mL-1). Neither sTNF-R55 nor sTNF-R75 were related to exposure, stage of pneumoconiosis, smoking, or (spontaneous or ex-vivo induced) monocyte TNF-release. sTNF-R55 was increased in subjects with medication (especially those using cardiovascular drugs); upon exclusion of these subjects, sTNF-R55 was found also to be significantly increased in CWP. In conclusion, bearing in mind a confounding effect of medication, soluble TNF receptors are elevated in plasma of retired miners with coal workers' pneumoconiosis. These observations further support the important...Continue Reading

Citations

Jan 19, 2000·Clinical Biochemistry·N A CobbenR F Henderson
Mar 7, 1998·Respiratory Medicine·N A CobbenM P Van Dieijen-Visser
Sep 23, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M GulumianJ Murray
Dec 17, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ilker AtesAsuman Karakaya
Mar 8, 2016·Journal of Occupational and Environmental Medicine·Nayara Felicidade Tomaz BrazVanessa Amaral Mendonça
May 9, 2014·Journal of Occupational and Environmental Medicine·Nayara Felicidade Tomaz BrazVanessa Amaral Mendonça

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