Plasma levels of the endocannabinoid anandamide, related N-acylethanolamines and linoleic acid-derived oxylipins in patients with migraine

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Sandra Gouveia-FigueiraChristopher J Fowler

Abstract

There is evidence that patients with migraine have deficient levels of the endogenous cannabinoid receptor ligand anandamide (AEA). It is not known, however, if this is a localised or generalised phenomenon. In the present study, levels of AEA, related N-acylethanolamines (NAEs) and linoleic acid-derived oxylipins have been measured in the blood of 26 healthy women and 38 women with migraine (26 with aura, 12 without aura) who were matched for age and body-mass index. Blood samples were taken on two occasions: the first sample near the start of the menstrual cycle (when present) and the second approximately fourteen days later. For a subset of migraine patients, two additional blood samples were taken, one during a migraine attack and one approximately 1 month later (to be at the same stage in the menstrual cycle, when present). NAEs and oxylipins were measured by liquid chromatography coupled to mass spectrometry. Twenty-nine lipids were quantified, of which 16 were found to have a high reproducibility of measurement. There were no significant differences in the levels of AEA, the related NAEs stearoylethanolamide and oleoylethanolamide or any of the nine linoleic acid-derived oxylipins measured either between migraine patient...Continue Reading

Citations

May 10, 2018·Frontiers in Pharmacology·Pinja LeimurantaRashid Giniatullin
Apr 5, 2018·Frontiers in Neuroscience·Rosaria GrecoCristina Tassorelli
Mar 19, 2019·Current Opinion in Neurology·Cristina TassorelliStephen D Silberstein
Feb 16, 2021·Frontiers in Pharmacology·Aidan LevineTally M Largent-Milnes
Jul 25, 2017·Prostaglandins & Other Lipid Mediators·Sandra Gouveia-FigueiraMalin L Nording

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