PMID: 6403963Jan 1, 1983Paper

Plasma levels of thiothixene by radioreceptor assay: clinical usefulness

Psychopharmacology
T Van PuttenB J Rosenberg

Abstract

Thirty-four newly admitted schizophrenic patients were treated with a fixed dose of thiothixene (0.44 mg/kg) for 4 weeks. Thiothixene and its active metabolites were measured by a new radioreceptor assay. Improvement occurred over the entire range of recorded plasma levels, but the chances of substantial improvement appear greater above 40 neuroleptic units (n.u.). The data do not support the notion of a "therapeutic window", in that higher plasma levels were not associated with side effects or clinical deterioration (although at extreme plasma levels this must of course be so). In 11 nonresponders dosage could not be increased because of side effects. If a non-responder with troublesome side effects has a low plasma level (less than 40 n.u.), it would seem prudent to switch to another antipsychotic drug.

References

Oct 29, 1976·Science·H Y Meltzer
Sep 1, 1978·Archives of General Psychiatry·P R May, T Van Putten
Jul 1, 1974·Archives of General Psychiatry·T Van Putten
Nov 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·B M AstrachanG Tucker
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Citations

Oct 1, 1996·Clinical Biochemistry·S J Soldin
Aug 1, 1993·Journal of Gerontological Nursing·P Krach
Jun 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·R G McCreadieC Menzies
May 1, 1988·Drug Intelligence & Clinical Pharmacy·J J SramekR Hahn
Mar 1, 1992·Annals of Clinical Biochemistry·S J Soldin

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