Plasma levels of thrombin activatable fibrinolysis inhibitor in normal and preeclamptic pregnant women

Thrombosis Research
Inci AlacacioğluBulent Undar

Abstract

To explain the pathogenesis of preeclampsia with coagulation induction or a defective fibrinolysis, various hemostatic parameters were studied and different treatment modalities targeting these parameters were evaluated. Considering the role of TAFI in down-regulation of fibrinolysis, in our study we have investigated whether TAFI contributes to impaired fibrinolysis in patient with preeclampsia. Thirty patients with preeclampsia (mean age +/- SD 25.7 +/- 4.53; range 17-36) and 30 normal pregnant women as control group (mean age +/- SD 28 +/- 5.26; range 21-38) were included in our study. TAFI antigen was determined using an ELISA kit for quantitative measurement. The mean TAFI antigen levels were 12.55 +/- 1.88 microg/ml in patients with preeclampsia and 12.29 +/- 3.0 microg/ml in normal pregnant women. A statistically significant difference was not found between TAFI antigen levels of two groups (p > 0.05). In order to clarify the role of TAFI in the pathogenesis of preeclampsia, in addition to plasma TAFI levels, its synthesis, activation and metabolism should also be evaluated.

References

Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
May 30, 1997·The Journal of Biological Chemistry·D V SakharovD C Rijken
Jul 1, 1997·Acta Obstetricia Et Gynecologica Scandinavica·R SchjetleinF Wisløff
Mar 17, 1999·Acta Obstetricia Et Gynecologica Scandinavica·R SchjetleinF Wisløff
Sep 26, 2001·Zeitschrift für Geburtshilfe und Neonatologie·L HeilmannW Rath
Oct 17, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·K A SchattemanD F Hendriks
Nov 28, 2001·British Journal of Haematology·P ChablozP de Moerloose
Jan 23, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Zarko AlfirevicVanessa Martlew
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Yasuko HoriYasuhiro Sumida
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·H AubertM C Alessi
Feb 9, 2008·Hypertension·James M Roberts, Janet M Catov

❮ Previous
Next ❯

Citations

May 19, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·A-S Ducloy-Bouthors
May 16, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yinghong ZhangXiaoping Zhang
Nov 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·M B PinheiroL M S Dusse
Sep 9, 2008·Fertility and Sterility·Silvia MasiniSergio Bernardini
Dec 23, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luci Maria SantAna DusseBashir A Lwaleed
Mar 17, 2006·Thrombosis Research·Waldemar UszyńskiEwa Zekanowska
Jan 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ilknur Inegol GumusSema Sevgili
Dec 1, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Suleyman GuvenS Caner Karahan
Aug 12, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ayla GokmenHuseyin Engin
Mar 20, 2020·International Journal of Laboratory Hematology·Sanja Lalic-CosicAleksandra Antovic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Yinghong ZhangXiaoping Zhang
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Elisabeth RoothJoven Antovic
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Bashir A LwaleedAlan J Cooper
© 2021 Meta ULC. All rights reserved