Plasma lipid concentrations and subsequent coronary occlusion after a first myocardial infarction. The POSCH Group

The American Journal of the Medical Sciences
J K BissettJ W Johnson

Abstract

This study correlated plasma lipid values with angiographic evidence of progression to complete coronary occlusion. Baseline triglycerides (TGs), total cholesterol (Chol), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol, and HDL/LDL and HDL/Chol ratios were compared with coronary angiograms taken at baseline, 3 and 5 years in a prospective angiographic study. Results were from part of the multicenter trial of plasma lipid reduction in patients after a single myocardial infarction (POSCH). Comparison of patient's baseline lipids in the absence or presence of a new total coronary occlusion at 3 years showed a significant difference (p = 0.01) in TGs of 197 +/- 147 versus 250 +/- 162 mg/dl (p = 0.02) and VLDL of 30 +/- 23 (n = 284) versus 40 +/- 30 (n = 49) mg/dl. Stratification by the mean HDL/Chol ratio (16%) demonstrated that baseline TG levels were significantly increased in patients with a new coronary occlusion by 3 years despite a higher HDL/Chol ratio. When measured at the 3-year visit, plasma TG (176 +/- 91 versus 212 +/- 146 mg/dl; p = 0.02) and VLDL (28 +/- 18 versus 35 +/- 29 mg/dl; p = 0.04) were significantly elevated in the presen...Continue Reading

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References

Aug 1, 1986·American Heart Journal·W P Castelli
Sep 1, 1980·Circulation·R B MooreR L Varco

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Citations

Sep 28, 1999·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·B S McCannR H Knopp
Apr 23, 2008·Journal of Cardiovascular Pharmacology·Madiha Abdel-MaksoudJohn E Hokanson
Nov 21, 2002·Current Opinion in Lipidology·Jean-Charles Fruchart, Patrick Duriez
May 3, 2006·Molecular and Cellular Biochemistry·Hussein M DashtiAbdulla I Behbahani

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