Abstract
Oxidative modifications of low-density lipoproteins (LDL) are considered to be important in the pathogenesis of atherosclerosis. However, the data on the association between LDL oxidation and severity of clinical manifestations of coronary artery disease (CAD) are contradictory. Previous reports were concerned mostly with unstable angina patients. The present study was undertaken to evaluate plasma lipid oxidation status in patients with stable CAD. 37 male patients with angiographically confirmed CAD (asymptomatic or suffering from stable angina pectoris) and 32 control subjects were used in the study. Plasma levels of vitamin E and products of lipid peroxidation, as well as parameters of the test for oxidizability of LDL in vitro were measured. We did not find differences between 2 groups of individuals regarding the levels of products of lipid peroxidation, vitamin E levels, lag time, maximal rate of oxidation, and total amount of conjugated dienes in the test for oxidizability of LDL. The results of our study challenge, but do not disprove, the oxidative hypothesis of atherosclerosis. Real atherosclerotic modifications of plasma LDL occur apparently in the vascular wall after trapping of LDL by the interstitial matrix. The ...Continue Reading
References
May 16, 1992·Lancet·J RegnströmA Hamsten
Mar 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P D ReavenJ L Witztum
Mar 3, 1992·Biochemical Pharmacology·A V BabiyK Willey
Feb 1, 1992·American Heart Journal·K Z LiuG N Pierce
Aug 1, 1991·Metabolism: Clinical and Experimental·A LavyM Aviram
May 1, 1990·Biomedical Chromatography : BMC·T MiyazawaS Oikawa
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Jan 1, 1987·Biology of the Neonate·M Orzalesi
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P AvogaroG Cazzolato
Sep 1, 1995·Journal of the American College of Cardiology·K MiwaM Fujita
May 1, 1995·Atherosclerosis·F J RaalM von Arb
Jan 6, 1995·Atherosclerosis·B AndrewsN Taub
Nov 1, 1994·Atherosclerosis·S R MaxwellG Bondjers
Sep 17, 1994·Lancet·J L Witztum
Nov 17, 1994·Biochimica Et Biophysica Acta·K KotaniM Manabe
Feb 1, 1994·European Heart Journal·J L Dubois-RandéY Grosgogeat
Aug 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H A KleinveldA F Stalenhoef
Mar 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A F StalenhoefJ J Kastelein
May 2, 1994·FEBS Letters·S P Gieseg, H Esterbauer
Jan 11, 1994·Biochimica Et Biophysica Acta·H C ChiuS M Shieh
Feb 1, 1993·Atherosclerosis·L CominaciniL Bertozzo
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Citations
Oct 31, 2008·Talanta·Vladimír BláhaZdenek Zadák
Sep 19, 2009·Journal of Nutritional Science and Vitaminology·Mansour KarajibaniMadhurima Dikshit
Oct 14, 2014·The American Statistician·Albert VexlerAlan D Hutson
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rosalia LoPrestiGregorio Caimi
Nov 27, 2014·Coronary Artery Disease·Gholamreza NamaziMorteza Pourfarzam
Apr 27, 2011·Biomedit︠s︡inskai︠a︡ khimii︠a︡·R K AĭdyralievA A Aldashev