Plasma lipidomic profiles after a low and high glycemic load dietary pattern in a randomized controlled crossover feeding study.

Metabolomics : Official Journal of the Metabolomic Society
Sepideh Dibay MoghadamJohanna W Lampe

Abstract

Dietary patterns low in glycemic load are associated with reduced risk of cardiometabolic diseases. Improvements in serum lipid concentrations may play a role in these observed associations. We investigated how dietary patterns differing in glycemic load affect clinical lipid panel measures and plasma lipidomics profiles. In a crossover, controlled feeding study, 80 healthy participants (n = 40 men, n = 40 women), 18-45 y were randomized to receive low-glycemic load (LGL) or high glycemic load (HGL) diets for 28 days each with at least a 28-day washout period between controlled diets. Fasting plasma samples were collected at baseline and end of each diet period. Lipids on a clinical panel including total-, VLDL-, LDL-, and HDL-cholesterol and triglycerides were measured using an auto-analyzer. Lipidomics analysis using mass-spectrometry provided the concentrations of 863 species. Linear mixed models and lipid ontology enrichment analysis were implemented. Lipids from the clinical panel were not significantly different between diets. Univariate analysis showed that 67 species on the lipidomics panel, predominantly in the triacylglycerol class, were higher after the LGL diet compared to the HGL (FDR < 0.05). Three species with FA...Continue Reading

Associated Clinical Trials

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Citations

Oct 13, 2021·Journal of the American Society for Mass Spectrometry·Baolong SuKevin J Williams

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Methods Mentioned

BETA
X-ray
PCA

Clinical Trials Mentioned

NCT00622661

Software Mentioned

LION
Analyst
web
Lipidomics Workflow Manager
MetaboAnalyst

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