Plasma Lipidomics of Healthy Japanese Adults Reveals Gender- and Age-Related Differences

Journal of Pharmaceutical Sciences
Keiko MaekawaYoshiro Saito

Abstract

Lipid metabolites in the blood are expected to be biomarker candidates to reflect disease states and responses to therapeutic drugs. However, their profiles are influenced by subject background, which may lead to confounding results. This study aimed to evaluate whether age and gender affect lipid metabolite levels in the plasma of healthy Japanese adults. Comprehensive lipidomic analysis was performed using liquid chromatography-mass spectrometry for overnight fasted volunteers consisting of 4 groups of 15 subjects each: young males (25-35 years), elderly males (55-64 years), young females (25-35 years), and elderly females (55-65 years). Of 326 detected lipids, none showed significant gender-associated differences in the young groups and 3 metabolites showed significant gender-associated differences in the elderly groups, suggesting that age has little impact on plasma lipid levels in Japanese subjects. We found age-associated differences in 111 (34%) and 115 (35%) metabolites in males and females, respectively, indicating that the subjects' age should be considered an important confounding factor for lipid biomarker exploration and validation studies in Japanese populations. These findings provide fundamental information on ...Continue Reading

References

Jul 27, 2010·Analytical Biochemistry·Linsheng LiuZimei Wu
Dec 24, 2010·Analytical Chemistry·Judith R DeneryTobin J Dickerson
Jul 16, 2011·PloS One·Zhonghao YuRui Wang-Sattler
Aug 20, 2011·PLoS Genetics·Kirstin MittelstrassThomas Illig
Aug 11, 2012·The Journal of Clinical Endocrinology and Metabolism·Catherine KimUNKNOWN Diabetes Prevention Program Research Group
Apr 3, 2013·Biological & Pharmaceutical Bulletin·Masaki IshikawaYoshiro Saito
Jul 25, 2013·Journal of Lipid Research·Martin FanDaniel S Ory
Sep 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Dorothee NewbernMichael Freemark
Jul 5, 2016·Biological & Pharmaceutical Bulletin·Kosuke SaitoYoshiro Saito
Oct 30, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Petroula ProitsiCristina Legido-Quigley
Dec 15, 2016·Scientific Reports·Bianca A M SchutteP Eline Slagboom

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Citations

Jan 12, 2020·Metabolomics : Official Journal of the Metabolomic Society·David BalgomaMikael Hedeland
May 6, 2021·Metabolites·Justin CarrardArno Schmidt-Trucksäss
Nov 24, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Sock Hwee TanMark Y Chan
Dec 9, 2021·The Journal of Clinical Endocrinology and Metabolism·Kai GuoEva L Feldman

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