PMID: 7082416Mar 1, 1982Paper

Plasma lipids and lipoproteins in Japanese male patients with coronary artery disease and in their relatives

Atherosclerosis
H KukitaT Kokubu

Abstract

Plasma cholesterol (CH), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were measured in 92 consecutive Japanese male subjects undergoing diagnostic coronary cineangiography. Sixty-nine of them were classified as having coronary artery disease (CAD), the remaining 23 subjects were classified as having normal coronary arteries (NCA). The CAD group had significantly lower HDL-C and higher TG levels than the NCA group. However, there was no significant difference in plasma CH between the two groups. First-degree relatives of the CAD patients were also investigated. The male blood relatives of the CAD patients also had significantly lower HDL-C and higher TG levels than the non-blood male relatives and healthy control males. The female blood relatives, however, showed no significant differences from the non-blood female relatives and the healthy control females in plasma CH, TG and HDL-C levels. These results suggest that low HDL-C and hypertriglyceridemia are the prevalent coronary risk factors, rather than hypercholesterolemia, in a population with a low fat intake such as the Japanese, and that these lipid abnormalities are related to sex and genetic factors.

References

Feb 5, 1976·The New England Journal of Medicine·G G RhoadsA Kagan
May 1, 1978·Atherosclerosis·R J GarrisonS J Padgett
Oct 1, 1979·Annals of Internal Medicine·M P Stern
Nov 5, 1977·British Medical Journal·R PelkonenS Sarna
Mar 1, 1976·Annals of Internal Medicine·P F CohnW B Weglicki
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Citations

Jul 1, 1994·The American Journal of Cardiology·G A LeidigG S Ginsburg
Sep 20, 2002·Journal of Atherosclerosis and Thrombosis·Yoshiya HataWorking Committee on JAS Guideline for Diagnosis and Treatment of Hyperlipidemias
Apr 20, 2011·Circulation·Michael MillerCouncil on the Kidney in Cardiovascular Disease
Apr 3, 1982·British Medical Journal·P V Scott, H B Fischer
Apr 3, 1982·British Medical Journal·P N Durrington, S A Cairns
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A Austin

Related Concepts

Alcohol Consumption
Epicholesterol
Coronary Heart Disease
Filiation
Hypertensive Disease
Alpha-1 Lipoprotein
Obesity
Cigar smoker
Triglycerides

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