Plasma lipids and other factors in the LA/N corpulent rat in the presence of chronic exercise and food restriction

Canadian Journal of Physiology and Pharmacology
J C Russell, R M Amy

Abstract

The effects of regular exercise and food restriction were studied in the LA/N corpulent rat up to age 9 months. This congenic strain of the Lister and Albany rat is normotensive, corpulent, and hyperlipidemic when homozygous for the corpulent (cp) gene derived from the Koletsky strain. Food restriction of corpulent animals to the intake of matched lean rats caused body weight to be significantly lower, although not as low as that of the lean animals. Plasma total cholesterol in freely eating sedentary corpulent animals was significantly higher (210 mg/100 mL) than in food-restricted rats (165 mg/100 mL), in which plasma cholesterol was considerably elevated compared with lean rats (80 mg/100 mL). Exercise caused a modest but significant increase in both total and high density lipoprotein cholesterol in both corpulent and lean rats. The rise was greater in corpulent rats and, in food-restricted exercising corpulent rats, the cholesterol concentrations were equivalent to those of freely eating corpulent animals. Systolic blood pressure in lean rats fell slowly from 146 mmHg at 8 weeks to 132 mmHg at 36 weeks and was not affected by exercise. Sedentary corpulent rats showed a rapid rise in systolic pressure from 107 mmHg at 7 week...Continue Reading

Citations

Sep 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C D BerdanierO E Michaelis
Jul 25, 1998·Atherosclerosis·M RichardsonJ C Russell
Oct 10, 2009·British Journal of Pharmacology·J C RussellS D Proctor
Feb 1, 1991·Experimental and Molecular Pathology·J C RussellP J Dolphin
Apr 3, 1999·The Journal of Biological Chemistry·L Y QiaoX J Sun
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J C RussellP J Dolphin
Jun 1, 1994·Circulation Research·C J McNameeJ C Russell
May 14, 2016·Circulation Research·Hamed MirzaeiValter D Longo
May 29, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·James C RussellSpencer D Proctor
May 1, 1997·Journal of Cardiovascular Pharmacology·J C RussellR M Amy
Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J C RussellP J Dolphin
Sep 5, 1998·The American Journal of Physiology·D B WestJ Scimeca
Jan 25, 2014·Journal of Applied Physiology·Daisuke ShindoMasato Suzuki
Oct 14, 1988·Biochimica Et Biophysica Acta·P J DolphinJ C Russell
Jun 2, 1987·Biochimica Et Biophysica Acta·P J DolphinJ C Russell
May 1, 1994·Metabolism: Clinical and Experimental·J C RussellM Hameed

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