Plasma lipids and vascular dysfunction in preeclampsia

Seminars in Reproductive Endocrinology
B Lorentzen, T Henriksen

Abstract

The dominating hypothesis of the preeclampsia syndrome (PES) is that placentally derived factors are released to the maternal circulation. These factors are believed to alter endothelial properties resulting in disturbed vasomotor function, increased endothelial permeability, and activation of thrombogenic factors. However, the impact of placentally derived factors on the endothelial cells is influenced by another major variable: the "sensitivity" of the maternal endothelium to the placental factors. Several maternal factors may play a role in determining this sensitivity. They include chronic hypertension, diabetes, and hyperlipidemia. In this article we discuss the possible role of hyperlipidemia (especially high free fatty acids and hypertriglyceridemia) in the pathogenesis of preeclampsia, viewed from this perspective. Pregnancy in general, preeclamptic pregnancy in particular, is associated with a marked hyperlipidemia. We suggest a parallel to atherosclerotic diseases, wherein hyperlipidemia induces endothelial dysfunction, probably by promoting oxidative stress in the arterial wall. The hyperlipidemia of pregnancy may have a similar effect on the endothelial cells. When placentally derived endothelial disturbing factors,...Continue Reading

Citations

Sep 1, 2006·Indian Journal of Clinical Biochemistry : IJCB·Jayanta DePradip Kumar Saha
Nov 13, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·T ClausenT Henriksen
Sep 21, 2013·Journal of Human Hypertension·K H LampinenR J Kaaja
Jan 15, 2002·Journal of Women's Health & Gender-based Medicine·S Yeo, S T Davidge
May 25, 2011·Hypertension·Caroline S EvansSanjeev G Shroff
Mar 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Arpita BasuTimothy J Lyons
Nov 26, 2013·Heart, Lung & Circulation·Francesca CharltonAnnemarie Hennessy
Feb 5, 2013·North American Journal of Medical Sciences·Madhusudan DeyReema Kumar
Jun 27, 2014·Journal of Obstetrics and Gynaecology of India·Kiran YadavKamlesh Verma
Jul 6, 2014·American Journal of Epidemiology·Cassandra N SpracklenKelli K Ryckman
Dec 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Daniel A EnquobahrieMichelle A Williams
Jan 14, 2011·Archives of Physiology and Biochemistry·B H KandimallaS S Maiya
Oct 20, 2015·Gynécologie, obstétrique & fertilité·P GuerbyA Negre-Salvayre
Oct 20, 2010·Paediatric and Perinatal Epidemiology·Emily W HarvilleMercedes Carnethon
Jun 17, 2011·The Journal of Obstetrics and Gynaecology Research·Oya DemirciSadiye Eren
Feb 26, 2000·Metabolism: Clinical and Experimental·H LaivuoriO Ylikorkala
Nov 10, 2004·Medical Hypotheses·G T R MantenArie Franx
Sep 28, 2006·The American Journal of Pathology·Scott W Walsh
Jun 29, 2015·Human Reproduction Update·Stefano PalombaBart C J M Fauser
Sep 24, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Mohammad Rasul JanTasleem Akhtar
Jan 4, 2001·Molecular Genetics and Metabolism·G TálosiI Németh
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Seongho RyuScott W Kauma
Jul 28, 2009·American Journal of Obstetrics and Gynecology·Arthur M BakerKim Boggess
Aug 24, 2001·American Journal of Obstetrics and Gynecology·T ClausenT Henriksen
May 29, 2004·American Journal of Obstetrics and Gynecology·Jennifer C DempseyDavid A Luthy
Jun 14, 2005·Biochimica Et Biophysica Acta·Christian A Drevon
Oct 6, 2005·American Journal of Obstetrics and Gynecology·Janette KhourySerena Tonstad
Jul 21, 2004·Atherosclerosis·Vanessa A RodieIan A Greer
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Thelma E PatrickJames M Roberts
Nov 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G T R MantenG H A Visser
May 4, 2004·Obstetrics and Gynecology·Mette Ree HoltheTorstein Lyberg
Nov 28, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivo BrosensGiuseppe Benagiano
May 17, 2005·Journal of Hypertension·Patricio López-JaramilloMarcos López
Jun 16, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Mette Ree HoltheTorstein Lyberg
Mar 24, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J G RayC M Bell
Oct 31, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·János RigóAgota Vér
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey S GilbertJoey P Granger
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P TakacsK Green
Feb 23, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Robert D CartwrightChristopher J D McKinlay
Mar 22, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Emiko AbeKenji Kameda
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Ralf L SchildYoel Sadovsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.