Abstract
To compare the relative impact of dietary lauric acid (12:0) and palmitic acid (16:0) on plasma lipids, two fat-sensitive species, Mongolian gerbils and cebus monkeys, were fed cholesterol-free, purified diets enriched with either 12:0-rich or 16:0-rich fats, while all other fatty acids were held constant by selective blending of up to five natural fats or oils. The two gerbil diets (40 en% from fat) allowed for an 8 en% exchange between 12:0 and 16:0, and the monkey diets (31 en% from fat) allowed for 6 en% exchange between these two fatty acids. Eight gerbils received the diets for eight weeks, and 12 cebus monkeys were fed each diet in a cross-over design for up to 22 wk. Both diets resulted in similar plasma cholesterol, triglyceride, and high density lipoprotein cholesterol concentrations within each species. Additionally, separation of cebus lipoproteins by discontinuous density-gradient ultracentrifugation failed to show any dietary differences in concentration or composition of the three major lipoprotein classes (d < 1.019, 1.019-1.055, and 1.055-1.168 g/mL). Thus, in two species sensitive to manipulations in dietary fat while consuming cholesterol-free diets, 16:0 was not hypercholesterolemic relative to 12:0.
References
Jun 15, 1978·Analytical Biochemistry·M A MarkwellN E Tolbert
Jan 1, 1992·Progress in Lipid Research·M I Gurr
Nov 1, 1992·The American Journal of Clinical Nutrition·M A Denke, S M Grundy
Aug 1, 1992·Journal of the American College of Nutrition·T K NgD Tan
Apr 1, 1992·The Journal of Clinical Investigation·L A WoollettJ M Dietschy
May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K C Hayes, P Khosla
Jan 1, 1992·The American Journal of Clinical Nutrition·P Khosla, K C Hayes
Feb 1, 1991·The American Journal of Clinical Nutrition·K C HayesD Diersen-Schade
Apr 24, 1991·Biochimica Et Biophysica Acta·P Khosla, K C Hayes
Mar 1, 1991·Lipids·A PronczukK C Hayes
Nov 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·S LindseyK C Hayes
Apr 1, 1989·The Journal of Nutrition·S M Grundy
May 1, 1988·Nutrition Reviews·D Kritchevsky
May 12, 1988·The New England Journal of Medicine·A Bonanome, S M Grundy
Aug 1, 1985·The American Journal of Clinical Nutrition·R ReiserW Insull
Oct 1, 1970·The American Journal of Clinical Nutrition·R B McGandyM L Myers
Nov 1, 1965·The American Journal of Clinical Nutrition·D M HegstedF J Stare
Feb 1, 1995·The Journal of Clinical Investigation·C J FieldingP H Frost
Nov 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A PronczukK C Hayes
Dec 1, 1994·The American Journal of Clinical Nutrition·S M Grundy
Apr 1, 1994·The American Journal of Clinical Nutrition·K SundramO H Siru
Dec 2, 1993·Biochimica Et Biophysica Acta·P Khosla, K C Hayes
Aug 1, 1993·The American Journal of Clinical Nutrition·M L Goldberg, M G Enig
Feb 1, 1993·The American Journal of Clinical Nutrition·K C Hayes
Jan 1, 1993·Metabolism: Clinical and Experimental·P M Kris-EthertonT A Pearson
Jul 1, 1965·Metabolism: Clinical and Experimental·Ancel KeysFrancisco Grande
Citations
Jan 1, 1996·Progress in Lipid Research·P Khosla, K Sundram
Dec 7, 2000·Progress in Lipid Research·R SambanthamurthiY Tan
Oct 16, 2003·The Journal of Nutritional Biochemistry·Vasuki WijendranK C Hayes
Aug 1, 1996·Journal of the American College of Nutrition·P Khosla, K C Hayes
Sep 18, 1997·Medical Hypotheses·C L Broadhurst