Plasma lipoprotein composition, apolipoprotein(a) concentration and isoforms in beta-thalassemia

Atherosclerosis
M MaioliR Fellin

Abstract

Patients with homozygous beta-thalassemia show an abnormal lipoprotein profile. In asymptomatic heterozygotes the lipid pattern is less markedly affected but interestingly related to a diminished cardiovascular risk. The extent and significance of these findings are still a matter of debate and no data are available on lipoprotein(a) plasma levels. Seventy patients with homozygous beta-thalassemia (HT-P), 70 beta-thalassemia trait carriers (TT-C) and 70 sex and age-matched controls were investigated and their plasma lipoprotein profile and apo(a) phenotypes determined. In a subgroup of these same subjects (12 HT-P, 12 TT-C and 24 controls) and in 12 bone marrow-transplanted homozygous beta-thalassemic patients (BMT-P) plasma lipoprotein composition was assessed. HT-P disclosed significantly lower total-cholesterol, LDL-cholesterol, HDL-cholesterol, apo A-I, apo B plasma levels and higher triglyceride concentration than TT-C (-7, -11, -8, -8, -13 and +11%, respectively) or controls (-39, -50, -46, -32, -30 and + 35%, respectively). All lipoprotein subclasses were triglyceride-enriched, while LDLs were also protein-enriched and HDLs protein-depleted. TT-C disclosed a small but significant reduction in apo A-I and apo B plasma lev...Continue Reading

Citations

Oct 7, 2005·International Journal of Cardiology·Constadina AggeliChristodoulos Stefanadis
Oct 9, 2007·Journal of Pediatric Hematology/oncology·Zuhal Yetkin AyDuran Canatan
Jul 29, 2009·Journal of Pediatric Hematology/oncology·Alpay CakmakOzcan Erel
Oct 31, 2012·Journal of Pediatric Hematology/oncology·Orhan GurselOkan Ozcan
May 10, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Rataya LuechapudipornUdom Chantharaksri
Jun 27, 2014·Indian Journal of Clinical Biochemistry : IJCB·Chintana SengsukSurapon Tangvarasittichai
Nov 15, 2014·Hemoglobin·Nassima Boudrahem-AddourBahia Djerdjouri
Nov 20, 2004·American Journal of Hematology·Flávio A NaoumRaul C Maranhão
Sep 5, 2007·Echocardiography·Omer GedikliDuran Canatan
Oct 10, 2006·Biochemical and Biophysical Research Communications·Noppawan Phumala MoralesUdom Chantharaksri
Jul 16, 2014·Disease Markers·Kamonlak LeecharoenkiatDuncan R Smith
Feb 15, 2015·Annals of Vascular Surgery·Thomas KotsisKonstantinos Speggos
Jul 2, 2011·Journal of Hepatology·Paola DongiovanniLuca Valenti
Apr 3, 2015·BioMed Research International·Adlette InatiHussein A Abbas
Dec 5, 2009·Hemoglobin·Azza A G TantawyShatha A G Amin
Sep 11, 1998·The American Journal of Gastroenterology·M CiccareseG Realdi

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.