Abstract
Preoperative plasma samples from coronary artery bypass surgery patients were analyzed for relative levels of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) in order to assess the HDL:LDL ratio as an indicator of risk for coronary heart disease. Fasting blood samples were drawn from bypass patients prior to surgery, and bypass patient mean plasma lipid data were compared with values from three other groups: randomly selected, newly admitted hospitalized patients; acutely ill student outpatients; and healthy hospital employees. Sudan Black B prestained plasma samples were electrophoresed on polyacrylamide gels, and HDL:LDL ratios were determined by densitometric gel scan and automatic peak integration. Of the four study groups, the bypass patient group had the lowest mean HDL:LDL ratio; the low ratios were due particularly to reduced levels of HDL2. Chemical analyses indicated that the bypass patient group also had lower mean HDL-cholesterol and higher mean total cholesterol and triglyceride levels than the other groups. When group age and sex differences were taken into account, the bypass group, especially males, also had low ratios. The results also strongly indicated that stresses involved with illness an...Continue Reading
References
Jan 4, 1975·Lancet·G J Miller, N E Miller
Apr 15, 1978·Lancet·D W Anderson
Feb 5, 1976·The New England Journal of Medicine·G G RhoadsA Kagan
Nov 1, 1976·Clinical Science and Molecular Medicine·G J MillerM T Ashcroft
May 1, 1977·Circulation·W P CastelliW J Zukel
Apr 1, 1978·Metabolism: Clinical and Experimental·J J AlbersW R Hazzard
Feb 1, 1978·Atherosclerosis·D W AndersonF T Lindgren
Jun 1, 1978·European Journal of Clinical Investigation·E A Nikkila
Jun 1, 1978·European Journal of Clinical Investigation·P AvogaroG Caturelli
Jan 1, 1978·Nutrition Reviews·K K Carroll
Jul 1, 1978·Circulation·J Stamler
Apr 12, 1976·JAMA : the Journal of the American Medical Association·B R BistrianJ Naylor
May 1, 1975·Atherosclerosis·L A Carlson, M Ericsson
Apr 1, 1976·Canadian Journal of Physiology and Pharmacology·J LelorierJ Davingnon
Dec 7, 1966·Biochimica Et Biophysica Acta·K A NarayanF A Kummerow
Oct 1, 1965·The American Journal of Clinical Nutrition·C M LeevyH Baker
Feb 8, 1980·JAMA : the Journal of the American Medical Association·M M Adner, W P Castelli
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Oct 1, 1958·Annals of Internal Medicine·D BRUNNER, K LOBL
May 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·H J McDONALD, L P RIBEIRO
Dec 28, 1964·Annals of the New York Academy of Sciences·L ORNSTEIN
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS