Plasma magnesium levels and treatment outcome in depressed patients

Nutritional Neuroscience
Giovanni CamardeseLuigi Janiri

Abstract

High, normal, or low plasma magnesium (Mg) levels have been observed in depressed patients. The aim of our study was to investigate the relationship of Mg levels with depression severity, specific psychopathological dimensions, and treatment outcome. A total of 123 outpatients during a major depressive episode were recruited. All patients showed at least two major depressive episodes and did not achieve remission in the former treatment trial. A blood sample was collected to determine total plasma Mg levels. The psychopathological status was assessed using Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Depression Retardation Rating Scale for psychomotor retardation, and Snaith-Hamilton Pleasure Scale for anhedonia. Hamilton Depression Rating Scale was repeated at 3 months after treatment. All patients showed Mg levels mostly within the normal range. No association between Mg levels and psychopathological severity was reported. Patients who responded to antidepressant treatment showed higher Mg levels and higher retardation scores at basal evaluation in comparison with non-responders. Although further studies investigating the relationship between hypomagnesaemia, depression, and treatment outcome are certainly...Continue Reading

References

Jan 1, 1989·International Journal of Psychiatry in Medicine·H H RasmussenI W Jensen
May 1, 1968·The American Journal of Psychiatry·J Mendels, C Cochrane
Jan 1, 1983·Acta Physiologica Scandinavica·T AkerstedtT Pollare
Jan 1, 1996·Neuropsychobiology·L T YoungR T Joffe
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D SoueryJ Mendlewicz
Jan 2, 2003·Nutritional Neuroscience·H Murck
Apr 23, 2003·Biological Psychiatry·A John RushSanjay Dubé
Mar 18, 2006·Medical Hypotheses·George A Eby, Karen L Eby
May 16, 2006·Trends in Genetics : TIG·Carrie E Bearden, Nelson B Freimer
Aug 29, 2007·Psychological Bulletin·Bonnie J KaplanJ Steven A Simpson
Sep 12, 2007·Archives of Medical Research·Lázaro Barragan-RodríguezFernando Guerrero-Romero
Jan 22, 2008·Biological Psychiatry·Dan V IosifescuPerry F Renshaw
Jun 19, 2008·Drug News & Perspectives·Cristina RodríguezJosé Martínez-González
Dec 9, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chandra C CardosoAna Lúcia S Rodrigues
Dec 17, 2008·The Australian and New Zealand Journal of Psychiatry·Felice N JackaArnstein Mykletun
Jun 23, 2009·Biological Trace Element Research·Kyu In JungChan Hee Song
Oct 30, 2009·The Journal of Nutrition·Philip P CavicchiaJames R Hébert
Dec 1, 2009·Medical Hypotheses·George A Eby, Karen L Eby

❮ Previous
Next ❯

Citations

Nov 26, 2013·Biological Trace Element Research·M StanisławskaE Grochans
Dec 15, 2012·Biological Trace Element Research·Teymoor YaryKourosh Soleimannejad
May 28, 2013·Archives of Psychiatric Nursing·Nancy Ho, Marilyn Sommers
Apr 2, 2013·Journal of Psychiatric Research·Harald Murck
Jan 17, 2013·Nutritional Neuroscience·Marie-Laure DeromMiguel A Martínez-González
Apr 2, 2015·Internal Medicine Journal·W CheungpasitpornS B Erickson
Sep 24, 2013·Journal of Affective Disorders·Magdalena Sowa-KućmaGabriel Nowak
Jun 14, 2018·BJPsych Open·Danny PhelanMarc Molendijk
Oct 25, 2013·Food & Function·Luana M ManossoAna Lúcia S Rodrigues
Jun 7, 2020·Nutrients·Andrea BotturiPaolo Brambilla
Jun 9, 2018·Nutrients·Anna E KirklandKathleen F Holton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Menopause : the Journal of the North American Menopause Society
Faustino R Pérez-LópezMARIA (MenopAuse RIsk Assessment) Research Group
Journal of the American Academy of Child and Adolescent Psychiatry
David H Rubin
© 2021 Meta ULC. All rights reserved