Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles

The British Journal of Nutrition
Jens LykkesfeldtHenrik E Poulsen

Abstract

It has been reported that smokers have higher plasma malondialdehyde concentrations compared with non-smokers. However, smokers have also consistently been shown to have a lower intake of fruits and vegetables as well as lower plasma antioxidant concentrations. Since both the latter issues may well influence the malondialdehyde concentration, we wanted to investigate if the observed difference between smokers and non-smokers was a result of differences in antioxidant status or if a more direct effect of smoking could also be isolated. In the present study, the plasma malondialdehyde and antioxidant profiles of a cohort of smokers (n 48) and non-smokers (n 32) were compared. While there was no significant difference in the major plasma antioxidants measured, i.e. ascorbic acid, alpha- and gamma-tocopherol and uric acid, we found a significant effect of smoking on plasma malondialdehyde (P=0.0003). Consequently, the present study suggests that lipid peroxidation as measured by plasma malondialdehyde is induced by smoking per se. While poor antioxidant status presumably also affects lipid peroxidation, it is only partly responsible for the increased level found in smokers in general.

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Citations

Oct 2, 2013·Indian Journal of Clinical Biochemistry : IJCB·Arun KumarV L Jindal
Mar 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jens Lykkesfeldt
Nov 25, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Suzanne B ColeConstance R Uphold
Feb 24, 2017·Rapid Communications in Mass Spectrometry : RCM·Sally A YatesSharon A Moore
Oct 17, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Safa Ali Ahmed AmarCanan Demir
Oct 12, 2019·Nutrients·Jens Lykkesfeldt, Pernille Tveden-Nyborg
Jan 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Justyna SzostakJulia Hoeng
May 23, 2019·International Journal of Toxicology·Fatemeh KhademiFatemeh Zal
Apr 1, 2020·Critical Reviews in Food Science and Nutrition·Anitra C Carr, Jens Lykkesfeldt
Dec 29, 2016·Open Access Macedonian Journal of Medical Sciences·Gordana KamcevaElisaveta Stikova
May 1, 2021·Nutrition Research Reviews·Emanuela AstoriIsabella Dalle-Donne

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