PMID: 2496247Mar 1, 1989Paper

Plasma manganese concentrations in infants and children receiving parenteral nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
K M HambidgeM A Goodall

Abstract

Manganese is excreted primarily via the bile. The objective of this study was to determine if plasma Mn concentrations were elevated in infants and children fed intravenously who developed cholestatic liver disease. An additional aim was to determine the Mn content of intravenous solutions. The study included nine subjects with normal liver function (group A) and five subjects who developed cholestatic liver disease while fed intravenously (group B). Serum total bilirubin in group B had been elevated for 1 wk to 5 months prior to entry into this study. Mean plasma Mn for group A was 0.79 +/- 0.18 ng/ml, which was similar to that for adult controls. The mean for group B was 3.06 +/- 2.07 ng Mn/ml which was significantly higher (p less than 0.005). Plasma Mn was correlated positively with serum total bilirubin (r = 0.874, p less than 0.001). In four group B subjects studied longitudinally, plasma Mn declined. This decline was associated with a decline in serum total bilirubin in one subject and both a decline in serum total bilirubin and a reduction in, or a cessation of, supplemental intravenous Mn in two subjects. In the fourth subject, hepatic dysfunction remained severe, but plasma Mn declined to a near normal value after dis...Continue Reading

References

Jun 1, 1985·The American Journal of Clinical Nutrition·C E CaseyM C Neville
Aug 1, 1984·Seminars in Liver Disease·J M Walshe
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·J KurkusM E Shils

❮ Previous
Next ❯

Citations

Mar 5, 1999·Biological Trace Element Research·P B Acosta, S Yannicelli
Jul 13, 2001·Nutrition·R N Dickerson
May 31, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Miyoung YoonHarvey J Clewell
Feb 12, 2002·Pharmacotherapy·Imad F Btaiche, Nabil Khalidi
Jul 28, 2010·Indian Journal of Anaesthesia·Koneru Veera Raghava Chowdary, Pothula Narasimha Reddy
Mar 4, 2005·Critical Reviews in Toxicology·Michael AschnerDavid C Dorman
Mar 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·E A BaylissJ R Lilly
May 3, 2007·Gastroenterology Clinics of North America·Andrew Ukleja, Michelle M Romano
Apr 24, 2004·Annals of the New York Academy of Sciences·Allison W DobsonMichael Aschner
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L Gallitelli
Nov 7, 2006·Pharmacology & Therapeutics·Keith M EriksonMichael Aschner
Mar 29, 2002·Clinics in Perinatology·Sandy T Hwang, Robert J Shulman
Nov 5, 2013·Neurotoxicology·Dinamene SantosMichael Aschner
Aug 16, 2005·Molecular Aspects of Medicine·Judy L Aschner, Michael Aschner
Oct 14, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J M ReimundB Duclos
Mar 22, 2000·Journal of Pediatric Surgery·S IkedaA Kotera
Apr 4, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·K MasumotoF Mihara
Apr 12, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Ines J HardyGil Hardy
Dec 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·T G Baumgartner
Jul 8, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·D B BertinetF Balzola
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·W W Koo
Nov 26, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·C A WardleA Shenkin
Nov 13, 2015·The American Journal of Clinical Nutrition·Judy L AschnerNathalie L Maitre
Nov 9, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·F Gidden, A Shenkin
Mar 24, 2016·F1000Research·Pan ChenMichael Aschner
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A Van Gossum, J Neve
Apr 9, 2020·Journal of Pediatric Gastroenterology and Nutrition·Jason B Sauberan, Anup C Katheria
Apr 27, 2001·American Journal of Industrial Medicine·J Zayed
Mar 4, 2003·The Journal of Nutrition·Michael Hambidge
Oct 7, 2004·Clinics in Liver Disease·V Kwan, J George

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.