Plasma matrix metalloproteinase-9 and ACE-inhibitor-induced improvement of urinary albumin excretion in non-diabetic, microalbuminuric subjects

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Ruud M A van de WalAdriaan A Voors

Abstract

Elevated plasma matrix metalloproteinase-9 (MMP-9) levels have been suggested to precede the development of microalbuminuria. As angiotensin-converting enzyme (ACE) inhibitors effectively reduce urinary albumin excretion (UAE), in the present study we have investigated the potential association of plasma MMP-9 levels with UAE and treatment effects of ACE-inhibition. In a placebo-controlled randomised trial we determined plasma MMP-9 levels at baseline and after three months of randomisation to either placebo (n=202) or fosinopril (20 mg/day, n=204) treatment. Baseline plasma MMP-9 levels were not related to baseline UAE (r=-0.008, p=0.871). Three months of fosinopril treatment effectively reduced UAE compared to placebo treatment (-10.4+/-2.4 vs. 1.8+/-1.3 mg/24 hours, p<0.001, respectively). However, fosinopril treatment failed to significantly change plasma MMP-9 levels compared to placebo (-0.47+/-7.68 vs. 0.06+/-9.20, p=0.646, respectively). In addition, the change in UAE was not related with change in MMP-9 levels. The effective reduction of UAE with fosinopril was not related to plasma MMP-9 levels.

References

Apr 1, 1989·Diabetologia·T DeckertA Kofoed-Enevoldsen
Oct 17, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I EbiharaH Koide
Aug 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·K Borch-JohnsenJ S Jensen
Jul 31, 2001·JAMA : the Journal of the American Medical Association·H C GersteinUNKNOWN HOPE Study Investigators
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Jean-Jacques BoffaChristos Chatziantoniou
Jul 8, 2003·The Journal of Pathology·Effie C Tsilibary
Jul 29, 2003·Diabetes Care·Kate V Allen, James D Walker
Sep 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Solfrid RomundstadHanne Ellekjaer
Apr 23, 2004·Journal of Clinical Laboratory Analysis·Kyoichi TashiroYasuhiko Tomino
Oct 20, 2004·Circulation·Folkert W AsselbergsUNKNOWN Prevention of Renal and Vascular Endstage Disease Intervention Trial (PREVEND IT) Investigators
Nov 2, 2004·The New England Journal of Medicine·Piero RuggenentiUNKNOWN Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) Investigators
Dec 13, 2005·International Journal of Cardiology·R M A van de WalA A Voors

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Citations

Jun 1, 2014·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
Nov 21, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alexandra M RochNicholas J Zyromski

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