Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?

Journal of Molecular Recognition : JMR
G VerebS Damjanovich

Abstract

Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.

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Citations

Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·A JeneiS Damjanovich
Oct 12, 2004·Cytometry. Part B, Clinical Cytometry·Hans-Juergen Seyfarth, Mario Koksch
Dec 14, 2007·The American Journal of Gastroenterology·Chung-Jyi TsaiEdward L Giovannucci
Jan 18, 2012·Clinical Science·Jeanette A M Maier
Mar 31, 2004·Canadian Journal of Physiology and Pharmacology·A T Anitha NandhiniC V Anuradha

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