Plasma membrane content of insulin-regulated glucose transporter in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a model of non-insulin-dependent diabetes mellitus

FEBS Letters
T SatoY Asahi

Abstract

The male Otsuka Long-Evans Tokushima Fatty (OLETF) rat shows insulin resistance in skeletal muscle and visceral obesity. To obtain information on the mechanism of the insulin resistance in the diabetic rats, we examined the content of insulin-regulated glucose transporter (GLUT4) in skeletal muscles. The results indicate that the total content of the transporter is significantly decreased (P < 0.05) in muscles of the diabetic rats. Plasma membrane content of the GLUT4 protein in muscles of the diabetic rats was increased in the basal state as compared to control rats. Hyperinsulinemic clamps increased GLUT4 levels in the plasma membrane of control rats but failed to do so in the diabetic rats. The distribution of GLUT4 in OLETF rat is reminiscent of the characteristics of human non-insulin-dependent diabetes mellitus.

References

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Citations

Jun 16, 2005·Diabetes, Obesity & Metabolism·Desu Chen, Ming-Wei Wang
Jan 22, 2014·Journal of Molecular Endocrinology·Ji Seon ParkKi Young Kim
May 27, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Ana AlonsoCelestino González
Nov 1, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sung Bum ParkKi Young Kim
Jan 15, 2008·Journal of Diabetes and Its Complications·Zhiyong GuoQin Huang
Apr 10, 2016·Environmental Toxicology and Pharmacology·Ling-Ling ChangPaulus S Wang
Sep 7, 2002·Hypertension·Tetsuya ShiuchiMasatsugu Horiuchi

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