PMID: 3756155Sep 25, 1986Paper

Plasma membrane lipid composition modulates action of anesthetics

Biochimica Et Biophysica Acta
W D Sweet, F Schroeder

Abstract

The effect of LM fibroblast plasma membrane phospholipid composition on the selectivity of charged amphipathic anesthetics for exofacial or cytofacial leaflets was examined. Because preference of charged amphipaths for one of the plasma membrane bilayer leaflets may be conferred by net changes in the polar headgroup composition, LM fibroblasts were cultured in the presence of choline or N-demethylated analogs in order to change this polar headgroup composition. These altered bases were incorporated into plasma membrane phospholipids. A significant difference in 1,6-diphenyl-1,3,5-hexatriene (DPH) limiting anisotropy was observed between plasma membrane leaflets of phosphatidylcholine-, but not phosphatidylethanolamine-enriched cells. Phenobarbital, which preferentially decreased the limiting anisotropy of 1,6-diphenyl-1,3,5-hexatriene in the exofacial leaflet, had little or no preferential effect in phosphatidyl-N,N-dimethylethanolamine-enriched membranes. Prilocaine preferentially reduced the limiting anisotropy of 1,6-diphenyl-1,3,5-hexatriene in the exofacial leaflet in phosphatidyl-N-methylethanolamine-enriched membranes, exactly opposite to its effect in phosphatidylcholine-enriched membranes. In contrast, prilocaine had n...Continue Reading

Citations

Jun 10, 2008·Lipids·Avery L McIntoshFriedhelm Schroeder
Jul 3, 2002·Chemistry and Physics of Lipids·Adalberto M GallegosFriedhelm Schroeder
Jun 1, 1989·Journal of Neurochemistry·W G WoodF Schroeder
Nov 1, 1996·Chemistry and Physics of Lipids·D M GoodmanP M Winter
Mar 12, 2003·Biochemical Pharmacology·Christopher KirschWalter E Mueller

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