Plasma membrane remodelling and cell stimulation

Médecine sciences : M/S
Maria Carmen MartínezJean-Marie Freyssinet

Abstract

For a long time the plasma membrane has been considered as a simple barrier between the extracellular and intracellular milieu. Now, it is well accepted that it plays a pivotal role in many physiological processes allowing the communication of cells with their environment. On the one hand, the plasma membrane directly participates in intracellular signaling, on the other hand, changes in membrane structure contribute to the transcellular transfer of biological information. This review analyses the most recent features concerning the plasma membrane plasticity, with a special focus on the intracellular signaling pathways involved in the regulation of the loss of membrane phospholipid asymmetry during cell activation. The pathophysiologic consequences of microparticle/microvesicle shedding from membrane blebs are briefly exposed.

References

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Citations

Jan 22, 2009·Médecine sciences : M/S·Loïc Doeuvre, Eduardo Angles-Cano
Mar 18, 2009·Arthritis Research & Therapy·Laurent MesserD Wachsmann
Aug 28, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Günter Müller
Oct 4, 2005·Médecine sciences : M/S·Yahsou DelmasJean Ripoche

Related Concepts

Blood Platelets
Plasma Membrane
Phospholipids
Signal Transduction

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