Plasma membrane signaling induced by ionizing radiation

Mutation Research
Isabelle CorreF Paris

Abstract

For decades, DNA has been considered as the main cellular target of deleterious effects of ionizing radiation (IR). Nevertheless, molecular signals initiated at cellular membranes are now identified as critical events in a large spectrum of radiation-induced cellular processes. If IR provokes DNA damage directly by energy deposit on the DNA double helix and indirectly by reactive species, origin of IR-induced molecular events initiated at the plasma membrane remains more obscure. Generation of reactive oxygen/nitrogen species (ROS/RNS) inducing proteins and lipids modifications seems to be the prevalent hypothesis. However, spatial and temporal relocalization of proteins and/or lipids represents also potential mechanisms of cell signaling generation. In the context of an oxidative stress such as IR, the best example is the translocation of the enzyme acid sphingomyelinase (ASMase) from lysosomes to the outer layer of cell membrane, which then induces sphingomyelin hydrolysis and ceramide formation. Ceramide coalescence with cholesterol forms lipids microdomains in the plasma membrane, enhancing clustering of signaling receptors (death receptors like FAS, TNF, CD40, TRAIL or G protein-coupled receptors). In this manuscript, we p...Continue Reading

Citations

Aug 7, 2013·Journal of Molecular Cell Biology·Hanna AppelqvistKarin Öllinger
Dec 25, 2013·Journal of Radiation Research·Masao S SasakiShunichi Takeda
May 28, 2013·The Cancer Journal·Andrei LaszloDennis E Hallahan
Aug 3, 2012·Radiation Oncology·Mohammed Yahia AlmaghrabiEmmanuel Rio
May 31, 2014·Cell Death & Disease·V MignardF M Vallette
Jan 3, 2014·Antioxidants & Redox Signaling·Julie A ReiszCristina M Furdui
May 28, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D N AntoniF Mornex
Jan 5, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J LacombeJ Solassol
Aug 28, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C KintzingerS Supiot
Feb 14, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S Supiot, F Paris
Sep 29, 2011·European Journal of Pharmacology·Govindasamy KanimozhiKodukkur Viswanathan Pugalendi
Sep 29, 2011·Advances in Biological Regulation·Ana Aguilar, Julie D Saba
May 7, 2011·Cancer Treatment Reviews·Renaud MazeronEric Deutsch
Jul 28, 2012·Aging Cell·Zhonghao YuRui Wang-Sattler
Mar 25, 2014·Journal of Cellular Physiology·Giuseppe CoronaGiuseppe Toffoli
Apr 12, 2016·Frontiers in Pharmacology·Natacha LeroiPhilippe Martinive
Feb 28, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Katja VoukTea Lanišnik Rižner
Jan 17, 2015·Cancer Letters·Suresh J HaikerwalNicole M Haynes
Oct 4, 2014·Pflügers Archiv : European journal of physiology·Bastian RothGerhard Thiel
Mar 8, 2013·Radiation Research·Stéphanie BlockhuysCarlos De Wagter
Jul 17, 2014·Radiation Research·David MurrayJeffrey L Schwartz
Feb 5, 2013·Radiation Research·Swati GirdhaniLynn Hlatky
Apr 9, 2015·Frontiers in Medicine·Jean-Pierre PougetIsabelle Navarro-Teulon
Apr 4, 2014·The Lancet Oncology·Gert De MeerleerMarc Mareel
Feb 6, 2015·Frontiers in Oncology·Eliot M RosenVijay K Singh
Apr 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nolwenn DuboisFrançois Paris
Aug 18, 2016·Cytoskeleton·Valeria PanzettaSabato Fusco
Sep 12, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D AntoniF Mornex
Apr 10, 2018·The British Journal of Radiology·Olivier GuipaudFabien Milliat
Sep 10, 2015·Scientific Reports·Christine S GibhardtGerhard Thiel
Sep 22, 2019·Cells·Wanyeon KimBuHyun Youn
Oct 30, 2019·Journal of Mass Spectrometry : JMS·Alisa O TokarevaGennady T Sukhikh
Sep 11, 2014·Human & Experimental Toxicology·Sf Salama, S A Montaser

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