Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course.

BMC Nephrology
Kyoungmi KimRobert H Weiss

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is characterized by gradual cyst growth and expansion, increase in kidney volume with an ultimate decline in kidney function leading to end stage renal disease (ESRD). Given the decades long period of stable kidney function while cyst growth occurs, it is important to identify those patients who will progress to ESRD. Recent data from our and other laboratories have demonstrated that metabolic reprogramming may play a key role in cystic epithelial proliferation resulting in cyst growth in ADPKD. Height corrected total kidney volume (ht-TKV) accurately reflects cyst burden and predicts future loss of kidney function. We hypothesize that specific plasma metabolites will correlate with eGFR and ht-TKV early in ADPKD, both predictors of disease progression, potentially indicative of early physiologic derangements of renal disease severity. To investigate the predictive role of plasma metabolites on eGFR and/or ht-TKV, we used a non-targeted GC-TOF/MS-based metabolomics approach on hypertensive ADPKD patients in the early course of their disease. Patient data was obtained from the HALT-A randomized clinical trial at baseline includi...Continue Reading

Associated Clinical Trials

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Citations

Feb 23, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Kristen L Nowak, Katharina Hopp
Sep 3, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yan-Ni WangYing-Yong Zhao
Mar 25, 2021·Scientific Reports·Madhurima M BaligaJelena Klawitter

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Methods Mentioned

BETA
nuclear magnetic resonance

Clinical Trials Mentioned

NCT00283686

Software Mentioned

R
Binbase
Leco ChromaTOF

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