Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes

Cardiovascular Diabetology
Naoto KatakamiIichiro Shimomura

Abstract

Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear. In this study, we aimed to identify the plasma metabolites associated with arterial stiffness in patients with type 2 diabetes mellitus. We used the metabolomic data of 209 patients with type 2 diabetes as the first dataset for screening. To form the second dataset for validation, we enlisted an additional 31 individuals with type 2 diabetes. The non-targeted metabolome analysis of fasting plasma samples using gas chromatography coupled with mass spectrometry and the measurement of brachial-ankle pulse wave velocity (baPWV) were performed. A total of 65 annotated metabolites were detected. In the screening dataset, there were statistically significant associations between the baPWV and plasma levels of indoxyl sulfate (r = 0.226, p = 0.001), mannitol (r = 0.178, p = 0.010), mesoerythritol (r = 0.234, p = 0.001), and pyroglutamic acid (r = 0.182, p = 0.008). Multivariate regression analyses revealed that the plasma levels of mesoerythritol were significantly (β = 0.163, p = 0.025) and that of indoxyl sulfate were marginally (β = 0.124, p = 0.076) associated with...Continue Reading

References

Aug 1, 1996·Journal of Pharmaceutical Sciences·S LiR T Borchardt
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaYoshio Yamamoto
Sep 6, 2003·The American Journal of Cardiology·Steven M Haffner
Jun 9, 2005·Journal of Atherosclerosis and Thrombosis·Hidenori AraiToru Kita
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Apr 25, 2007·Hypertension·Stéphane Laurent, Pierre Boutouyrie
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jul 28, 2009·Nutrition·Gertjan J M den HartogAalt Bast
May 1, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ichiro MiyanoYoshinori Doi
Jun 18, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tanvir Chowdhury TurinHirotsugu Ueshima
Jul 17, 2012·International Journal of Cardiology·Bummei SatoToyoaki Murohara
Oct 30, 2013·Clinical and Experimental Hypertension : CHE·Ji-Hyun KimChan-Joo Kim
Apr 23, 2014·Bioinformatics·Hiroshi TsugawaMasanori Arita
May 9, 2014·Journal of the American Society of Nephrology : JASN·Raymond VanholderGriet Glorieux
Sep 6, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alice SabatinoEnrico Fiaccadori
Apr 25, 2015·Stroke; a Journal of Cerebral Circulation·Xiao-Hui DongHe-Hui Xie
May 6, 2015·Nature Methods·Hiroshi TsugawaMasanori Arita
Nov 23, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ali RamezaniDominic S Raj
Sep 30, 2016·Journal of Clinical Lipidology·Antonino Di PinoAgata Maria Rabuazzo
Feb 9, 2017·Journal of the American Heart Association·Szu-Chun HungDer-Cherng Tarng
Mar 9, 2017·Current Diabetes Reports·Alice SabatinoEnrico Fiaccadori
Mar 23, 2017·Journal of Atherosclerosis and Thrombosis·Takashi MiidaTamio Teramoto
Jul 26, 2017·Bioscience Reports·Astrid KehlenHans-Ulrich Demuth
Oct 3, 2017·Journal of Atherosclerosis and Thrombosis·Naoto Katakami
Oct 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Antonino Di PinoAgata Maria Rabuazzo
Mar 23, 2018·Cardiovascular Diabetology·Sang Bae LeeJong Suk Park
Mar 28, 2018·Journal of Diabetes Investigation·Masakazu HanedaEiichi Araki
Nov 7, 2019·Cardiovascular Diabetology·Marcello Ricardo Paulista MarkusMarcus Dörr

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Methods Mentioned

BETA
metabolomics profiling

Software Mentioned

SPSS
MS
DIAL

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