Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults.

Journal of Neurochemistry
Pratishtha ChatterjeeRalph Martins

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no cure. Identifying biochemical changes associated with neurodegeneration prior to symptom onset, will provide insight into the biological mechanisms associated with neurodegenerative processes, that may also aid in identifying potential drug targets. The current study therefore investigated associations between plasma neurofilament light chain (NF-L), a marker of neurodegeneration, with plasma metabolites that are products of various cellular processes. Plasma NF-L, measured by ultrasensitive Single molecule array (Simoa) technology (Quanterix) and plasma metabolites, measured by mass-spectrometry (AbsoluteIDQ® p400HR kit, BIOCRATES), were assessed in the Kerr Anglican Retirement Village Initiative in Ageing Health (KARVIAH) cohort comprising 100 cognitively normal older adults. Metabolites belonging to biogenic amine (creatinine, symmetric dimethylarginine, asymmetric dimethylarginine; ADMA, kynurenine, trans-4-hydroxyproline), amino acid (citrulline, proline, arginine, asparagine, phenylalanine, threonine) and acylcarnitine classes were observed to have positive correlations with plasma NF-L, suggesting a link between neurodegeneration a...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1989·Mechanisms of Ageing and Development·D CurtiF Marzatico
Aug 12, 1971·The New England Journal of Medicine·J P Kassirer
Nov 9, 1995·The New England Journal of Medicine·T PolvikoskiK Kontula
Feb 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P PiovesanL Angelucci
Jan 1, 1993·Neurobiology of Aging·S DavisC A Barnes
Jul 11, 1998·Journal of Neural Transmission·F J Jiménez-JiménezJ Arenas
Jul 15, 1999·Journal of Psychosomatic Research·R C van der MastJ D Habbema
May 20, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J M Flacker, L A Lipsitz
Sep 6, 2000·Kidney International·R J Schmidt, C Baylis
Oct 24, 2000·European Journal of Pediatrics·R Surtees, N Blau
Aug 30, 2002·Neurochemical Research·Sirakarnt DhitavatEzequiel R Rivera
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Stephen L SeligerLew H Kuller
Jul 28, 2004·The American Journal of Clinical Nutrition·Giovanni RavagliaErminia Mariani
May 13, 2005·Journal of the American Society of Nephrology : JASN·Manjula KurellaKristine Yaffe
Jun 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan T KielsteinDanilo Fliser
Jul 12, 2008·Dementia and Geriatric Cognitive Disorders·Sönke ArltRainer H Böger
May 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thorleif EtgenHorst Bickel
Aug 1, 2009·Stroke; a Journal of Cerebral Circulation·Aleksandra PikulaSudha Seshadri
Aug 28, 2009·Seminars in Dialysis·Peter Paul De DeynGriet Glorieux
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Minesh KhatriClinton B Wright
Jul 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan T KielsteinVolker Kliem
Nov 26, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Kay A LawtonJames D Berry
Mar 8, 2012·Investigative Ophthalmology & Visual Science·Shahrbanou JavadiyanJamie E Craig
Jun 9, 2012·Nature Reviews. Neuroscience·Robert SchwarczHui-Qiu Wu
Nov 28, 2012·Neurobiology of Aging·Priya RajagopalanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 30, 2012·European Archives of Psychiatry and Clinical Neuroscience·Markus J SchwarzHarald Hampel
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Oct 26, 2013·Current Alzheimer Research·Mark McEvoyJohn Attia
Nov 28, 2013·The FEBS Journal·Sophia Schedin-WeissLars O Tjernberg

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Citations

Dec 12, 2020·International Journal of Molecular Sciences·Nóra TörökLászló Vécsei
Dec 29, 2020·Journal of Alzheimer's Disease : JAD·Pratishtha ChatterjeeUNKNOWN Dominantly Inherited Alzheimer Network
Nov 18, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nicholas M PajewskiJeff D Williamson

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