Plasma metabolites predict both insulin resistance and incident type 2 diabetes: a metabolomics approach within the Prevención con Dieta Mediterránea (PREDIMED) study

The American Journal of Clinical Nutrition
Christopher PapandreouJordi Salas-Salvadó

Abstract

Insulin resistance is a complex metabolic disorder and is often associated with type 2 diabetes (T2D). The aim of this study was to test whether baseline metabolites can additionally improve the prediction of insulin resistance beyond classical risk factors. Furthermore, we examined whether a multimetabolite model predicting insulin resistance in nondiabetics can also predict incident T2D. We used a case-cohort study nested within the Prevención con Dieta Mediterránea (PREDIMED) trial in subsets of 700, 500, and 256 participants without T2D at baseline and 1 and 3 y. Fasting plasma metabolites were semiquantitatively profiled with liquid chromatography-tandem mass spectrometry. We assessed associations between metabolite concentrations and the homeostasis model of insulin resistance (HOMA-IR) through the use of elastic net regression analysis. We subsequently examined associations between the baseline HOMA-IR-related multimetabolite model and T2D incidence through the use of weighted Cox proportional hazard models. We identified a set of baseline metabolites associated with HOMA-IR. One-year changes in metabolites were also significantly associated with HOMA-IR. The area under the curve was significantly greater for the model c...Continue Reading

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Citations

May 22, 2020·Circulation Research·Zsu-Zsu Chen, Robert E Gerszten
Sep 26, 2019·Frontiers in Aging Neuroscience·Jaume FolchAntoni Camins
Feb 23, 2020·International Journal of Molecular Sciences·Uma V MahajanMadhav Thambisetty
Jul 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Sha DiXiaolin Tong
Feb 10, 2021·Scientific Reports·Francisco Félix CaballeroEsther Lopez-Garcia
Jun 16, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Serena GaliéMònica Bulló
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Youli WangJianmin Yuan

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