Plasma Metabolomic Profiles and Risk of Advanced and Fatal Prostate Cancer.

European Urology Oncology
Ying WangVictoria L Stevens

Abstract

Little is known about the underlying molecular mechanisms of prostate cancer, especially advanced and fatal prostate cancer. To examine associations of prediagnostic plasma metabolomic profiles with advanced and fatal prostate cancer. In a case-cohort study of the Cancer Prevention Study-II Nutrition Cohort, of 14 210 cancer-free men with a blood sample in 1998-2001, 129 were diagnosed with advanced prostate cancer (T3-T4 or N1 or M1) through June 2013 and 112 died from prostate cancer through December 2014. Plasma samples from advanced and fatal cases, and a randomly selected subcohort of 347 men were metabolically profiled using untargeted mass spectroscopy-based platforms. Prentice-weighted Cox proportional hazards regression models were used to assess associations of 699 known metabolites with advanced and fatal prostate cancer. Two metabolites derived from fatty acid metabolism (ethylmalonate and butyrylcarnitine), aspartate, sphingomyelin (d18:1/18:0), and two γ-glutamyl amino acids (γ-glutamylmethionine and γ-glutamylglutamine) were statistically significantly associated (false discovery rate <0.2) with fatal prostate cancer. One standard deviation (SD) increase in each γ-glutamyl amino acid was associated with 34-38% de...Continue Reading

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Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Ying WangVictoria L Stevens
Apr 2, 2019·European Urology Oncology·Francesca GiunchiMassimo Loda

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Citations

Apr 2, 2020·Cancer Medicine·Jen-Tsan ChiStephen J Freedland
Feb 26, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xiaoshuang FengLorelei A Mucci
May 28, 2021·Journal of Separation Science·Jonathan B ThackerSubramaniam Pennathur

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