Plasma Metabolomic Profiling Associates Bicuspid Aortic Valve Disease and Ascending Aortic Dilation with a Decrease in Antioxidant Capacity

Journal of Clinical Medicine
Neus Martínez-MicaeloJosep M Alegret

Abstract

The bicuspid aortic valve (BAV) is the most common cardiac congenital disease and is associated with an increased risk of developing ascending aorta dilation; which can have fatal consequences. Currently; no established risk biomarkers exist to facilitate the diagnosis and prognosis of BAV. Using an untargeted metabolomic approach; we identified the levels of metabolites in plasma samples and compared them depending on the bicuspid or tricuspid morphology of the aortic valve. Including those patients with ascending aortic dilation and/or aortic stenosis (n = 212), we analyzed the role possibly played by alpha-Tocopherol in BAV disease; considering its association with the pathophysiological characteristics of BAV and biomarkers related to inflammation, oxidative stress and endothelial damage, as well as characteristics related to alpha-Tocopherol functionality and metabolism. We found that BAV patients; especially those with ascending aortic dilation; presented lower antioxidant capacity; as determined by decreased plasma levels of alpha-Tocopherol; paraoxonase 1 and high-density lipoprotein (HDL), as well as increased levels of C-reactive protein (CRP; a biomarker of inflammation) and endothelial microparticles (EMPs; an endot...Continue Reading

References

Apr 1, 1982·The American Journal of Clinical Nutrition·W A BehrensR Madère
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Sep 1, 2005·Current Problems in Cardiology·Alan C BravermanMarc R Moon
Apr 29, 2006·Journal of Cardiovascular Medicine·Moreno CecconiGian Piero Perna
Sep 30, 2008·Journal of Magnetic Resonance Imaging : JMRI·Tadhg G GleesonJohn G Murray
Mar 12, 2010·Advances in Experimental Medicine and Biology·Michal Efrat, Michael Aviram
Dec 3, 2011·Current Opinion in Gastroenterology·Karen D Corbin, Steven H Zeisel
Jan 29, 2013·BioFactors·Gabriella FanaliAngelo Azzi
Mar 14, 2014·Redox Biology·Maria WallertStefan Lorkowski
Feb 9, 2016·Computer Methods and Programs in Biomedicine·Christopher CostaMiguel Rocha
May 15, 2016·International Journal of Cardiology·Josep M AlegretRaúl Beltrán-Debón
Nov 16, 2016·Scientific Reports·Wenshuo WangLai Wei
Apr 13, 2017·Journal of Translational Medicine·Neus Martínez-MicaeloJosep M Alegret
May 5, 2017·Nutrients·Steven Zeisel
Mar 15, 2018·Journal of Inherited Metabolic Disease·Ilya Gertsman, Bruce A Barshop
Apr 20, 2018·Journal of Cardiovascular Development and Disease·Froso SophocleousGiovanni Biglino
Apr 27, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·José Fernando Rodríguez-PalomaresArturo Evangelista
Jul 13, 2019·Current Problems in Cardiology·Alessandro Della CorteAmalia Forte
Jan 17, 2020·Journal of Clinical Medicine·Evaldas GirdauskasYskert von Kodolitsch

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Citations

Apr 30, 2021·Circulation Research·Mark C BlaserElena Aikawa
Jun 3, 2021·International Journal of Molecular Sciences·Alejandro Junco-VicenteIsabel Rodríguez
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Massimo ChessaVassilios Fanos

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Methods Mentioned

BETA
dissection
metabolomic profiling
flow cytometry
reverse-phase chromatography

Software Mentioned

R Bioconductor
R
XCMS
SPSS
randomForest
specmine
Bioconductor

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