Plasma microRNA Array Analysis Identifies Overexpressed miR-19b-3p as a Biomarker of Bipolar Depression Distinguishing From Unipolar Depression

Frontiers in Psychiatry
Yu ChenQing Lu

Abstract

The clinical characteristics of bipolar disorder (current major depressive episode) (BD) overlap with unipolar depressive disorder (UD), which makes it difficult to perform an accurate diagnosis. We identified plasma microRNAs (miRNAs) that distinguished BD from UD and explored the relationship between miRNA expression levels and clinical characteristics. Total miRNAs from blood plasma from seven UD patients, seven BD patients, and six controls were analyzed. The identified miRNAs were validated in a separate population group. Depression severity and early life adversities were assessed. Bioinformatic analysis was conducted to investigate the target genes that were identified and the pathways associated with the altered miRNAs. Compared to controls, 42 miRNAs were differentially expressed in patients. miR-19b-3p, miR-3921, and miR-1180-3p were selected to validate the microarray results. Only miR-19b-3p was validated as down-regulated in patients. The primary predicted genes associated with miR-19b-3p were MAPK1, PTEN, and PRKAA1. The most relevant KEGG pathways included mTOR, FoxO, and the PI3-K/Akt signaling pathway. BD patients were more likely to have higher expression levels of miR-19b-3p and more severe childhood trauma e...Continue Reading

References

Aug 1, 1994·The American Journal of Psychiatry·D P BernsteinJ Ruggiero
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Feb 20, 2003·The Journal of Clinical Psychiatry·Robert M A HirschfeldKaren D Wagner
May 14, 2003·Archives of General Psychiatry·Peter McGuffinAlastair Cardno
Sep 24, 2004·Cellular Signalling·Marie A Bogoyevitch, Naomi W Court
Jun 6, 2007·Bipolar Disorders·Ross J BaldessariniIrene M Bratti
Sep 14, 2007·Journal of Affective Disorders·Claire O'DonovanMartin Alda
Sep 18, 2007·Journal of Affective Disorders·E VietaUNKNOWN EDHIPO Group (Hypomania Detection Study Group)
Aug 19, 2008·Journal of Affective Disorders·Lauren B MarangellMichael H Allen
Apr 3, 2010·Neuroscience and Biobehavioral Reviews·Michael B HennessyPatricia A Schiml-Webb
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Ronald C KesslerDavid R Williams
Mar 9, 2011·Archives of General Psychiatry·Kathleen R MerikangasZahari Zarkov
Mar 23, 2012·Trends in Neurosciences·Heh-In Im, Paul J Kenny
Jun 12, 2012·Nucleic Acids Research·Michael P GantierBryan R G Williams
Jun 7, 2013·Science Translational Medicine·Raül AnderoKerry J Ressler
Aug 21, 2013·Molecular Psychiatry·H Le-NiculescuA B Niculescu
Nov 12, 2013·Acta Psychiatrica Scandinavica·R CoelhoR Grassi-Oliveira
Mar 4, 2014·Life Sciences·Helena M AbelairaJoão Quevedo
Feb 25, 2015·Journal of Psychiatric Research·Rosie May WalkerKathryn Louise Evans
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yuncai Chen, Tallie Z Baram
Jan 15, 2016·International Journal of Bipolar Disorders·Monica AasBruno Etain
May 7, 2016·Journal of Affective Disorders·Elisabetta MaffiolettiLuisella Bocchio-Chiavetto
Jun 19, 2016·Progress in Neurobiology·Sharon L Hollins, Murray J Cairns
Oct 21, 2016·Molecular Psychiatry·B Ludwig, Y Dwivedi
Dec 7, 2016·Journal of Experimental & Clinical Cancer Research : CR·Teng HuangXia He
Apr 30, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ather Muneer
May 4, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elísabet Alcocer-GómezMario D Cordero
Aug 5, 2017·International Journal of Molecular Sciences·Anke HoffmannDietmar Spengler
Nov 11, 2017·The Journal of Experimental Medicine·Priti B SinghK Mark Ansel

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Molecular Sciences·Soudeh Ghafouri-FardSerge Brand

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE152267

Methods Mentioned

BETA
chips
PCR
chip

Software Mentioned

Cytoscape
R
TargetScan
Affymetrix GeneChip Command Console
SPSS

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.