Plasma microRNAs as biomarkers for Lamin A/C-related dilated cardiomyopathy

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Rocio ToroDavid de Gonzalo-Calvo

Abstract

Lamin A/C gene (LMNA)-related familial dilated cardiomyopathy (fDCM) is an aggressive heart disease that often leads to transplantation and sudden death. The aim of our study was to evaluate the circulating microRNA (miRNA) profiles of patients with LMNA pathogenic mutations. The study population (N = 75) included (i) patients with pathogenic LMNA mutations responsible for fDCM (LMNAMUT), (ii) age- and sex-matched LMNA wild-type controls (LMNAWT control), and (iii) LMNA wild-type idiopathic DCM (iDCM) patients (LMNAWT iDCM). Detailed clinical information was obtained from each participant. A panel of 179 plasma miRNAs was evaluated using RT-qPCR. An initial screening study was performed in LMNAMUT carriers and age-matched LMNAWT controls (N = 16). Forty-four miRNAs were specifically deregulated in LMNAMUT carriers. Ten miRNA candidates were selected for subsequent validation after coexpression analyses and filtered for expression levels and statistical significance. Among the candidates, let-7a-5p, miR-142-3p, miR-145-5p and miR-454-3p levels were significantly increased in LMNAMUT carriers compared to LMNAWT controls and iDCM patients (P < 0.050). These circulating miRNAs, and their combination, were also associated with the p...Continue Reading

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Citations

Oct 6, 2020·BioMed Research International·Kai HuangXiaotian Sun
May 30, 2019·Journal of Internal Medicine·David de Gonzalo-CalvoVicenta Llorente-Cortés
Aug 29, 2020·Cellular & Molecular Biology Letters·Kota OgawaTakashi Iwamoto
Jan 25, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yudong WuDongming Xing
Oct 15, 2020·Revista Española De Cardiología·Maria Calderon-DominguezRocío Toro
Mar 31, 2021·Revista Española De Cardiología·Sandra Sánchez-EstebanMarta Saura
Apr 8, 2021·Scientific Reports·Maria Calderon-DominguezRocio Toro
May 22, 2021·Journal of the American College of Cardiology·Diane FatkinJason C Kovacic
Sep 10, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marina C CostaRocío Toro

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Methods Mentioned

BETA
PCR

Software Mentioned

CDS
DIANA
miRPath
microT
SDS

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