Plasma microRNAs Predict Chemoresistance in Patients With Metastatic Breast Cancer

Technology in Cancer Research & Treatment
Bin ShaoHuiping Li

Abstract

MicroRNAs contribute to chemotherapy response in different types of cancer. We hypothesized that plasma miRNAs are potentially associated with chemotherapy response in patients with metastatic breast cancer. Fourteen candidate microRNAs were chosen from the literature, and their plasma levels were measured by quantitative polymerase chain reaction (PCR). Forty metastatic breast cancer patients were chosen as the training groups. The potential significant microRNAs were validated in another 103 plasma samples. In the training set, we identified 3 microRNAs (miR-200a, miR-210, and miR-451) as significantly dysregulated miRNAs between sensitive group (partial response (and stable disease) and resistant group (progressive disease). Then, in the validation set, miR-200a (area under the curve = 0.881, sensitivity = 94.1%, specificity = 76.7%) and miR-210 (area under the curve = 0.851, sensitivity = 88.2%, specificity = 72.1%) showed high diagnostic accuracy for distinguishing sensitive group from resistant group. Furthermore, the plasma level of miR-200a was significantly associated with the stage in surgery ( P = .035), and the high level of miR-210 expression was associated with internal organ metastasis (liver, lung, and brain; P ...Continue Reading

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Citations

Mar 17, 2020·Current Pharmaceutical Design·Carolin J CurtazMalgorzata Burek
Oct 9, 2019·International Journal of Molecular Sciences·Hui-Yi LohMohd Azuraidi Osman
Jan 12, 2021·Journal of Experimental & Clinical Cancer Research : CR·Muhlis AkmanChiara Riganti
Oct 12, 2021·Experimental and Therapeutic Medicine·Liu-Jing WenPei-Yi Tan

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Methods Mentioned

BETA
PCR

Software Mentioned

GeNorm
NormFinder
SPSS

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