Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: Results from the observational DIAST-CHF study in patients with cardiovascular risk factors

Psychoneuroendocrinology
Thomas MeyerFrank Edelmann

Abstract

It has been postulated that patients with heart failure have a high risk of ventricular arrhythmias and sudden cardiac death resulting from anxiety-induced autonomic arousal. In the prospective and multicenter DIAST-CHF (Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure) study, we therefore, tested the hypothesis that adrenomedullin (ADM), a well-established predictor for cardiovascular outcome, is associated with self-rated anxiety symptoms in patients at risk of suffering from or actually with overt heart failure. Study participants with risk factors for diastolic dysfunction were requested to complete the Hospital Anxiety and Depression Scale (HADS), and plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations were measured. In bivariate analysis, we found significantly lower plasma MR-proADM levels in patients with elevated HADS-anxiety scores above the clinically relevant cut-off level of ≥11 (n=118, 536pmol/l, interquartile range [IQR] 449-626) as compared to non-anxious study participants (n=1,292, 573pmol/l, IQR 486-702, p=0.001). A set of multivariate models adjusted for potential confounders confirmed the negative association between self-rated anxiety symptoms and ...Continue Reading

References

Apr 26, 2002·Journal of Cardiovascular Pharmacology·Noritoshi NagayaKenji Kangawa
Jul 9, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·S YükselM Yürekli
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio NishikimiHiroaki Matsuoka
Jul 29, 2003·Psychosomatic Medicine·Christoph Herrmann-LingenBurkert Pieske
Aug 19, 2003·European Journal of Pharmacology·Christian JuanedaRémi Quirion
Aug 16, 2005·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Apr 4, 2006·Amino Acids·B Yanagawa, N Nagaya
Apr 18, 2006·Pharmacology & Therapeutics·Toshihiko IshimitsuHiroaki Matsuoka
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ana P FernándezAlfredo Martínez
Apr 18, 2009·Journal of the American College of Cardiology·Heidi T MayA Peter Catinella
Feb 7, 2012·The American Journal of Cardiology·Yang XueAlan Maisel
Jun 12, 2013·Current Protein & Peptide Science·Toshio NishikimiKazuwa Nakao
Feb 16, 2015·The American Journal of Cardiology·Matthew F YuyunLeong L Ng

❮ Previous
Next ❯

Citations

Feb 13, 2018·BioPsychoSocial Medicine·Hans-Christian DeterStephan Zipfel
Oct 8, 2020·BioPsychoSocial Medicine·Monika SadlonovaChristoph Herrmann-Lingen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.